TY - JOUR

T1 - Izuchenie vliianiia bis(n-tributilolovo)-oksida na GAMK-ergicheskuiu sistemu mozga in vitro.

AU - Gerasimiak, G. R.

AU - Rozanov, V. A.

AU - Shafran, L. M.

PY - 1994/3/1

Y1 - 1994/3/1

N2 - Wide concentration range (10(-14)-10(-4) M) of bis-(n-tributyltin)-oxide effect on Na(+)-dependent uptake, spontaneous and K(+)-stimulated release, specific receptor binding and GABA metabolism were studied in vitro experiments using brain slices, synaptic membrane fraction and brain tissue homogenates. It is shown that the dependence "concentration-effect" is of non-linear character in all cases. Prevailing suppression of Na(+)-dependent uptake and specific receptor binding during K(+)-stimulated release and metabolism (production and utilization) of GABA activation were marked as a general tendency. Mechanisms of TBTO effect on the studied processes and the involvement of GABA-ergic system in realization of TBTO neurotoxic effects are discussed.

AB - Wide concentration range (10(-14)-10(-4) M) of bis-(n-tributyltin)-oxide effect on Na(+)-dependent uptake, spontaneous and K(+)-stimulated release, specific receptor binding and GABA metabolism were studied in vitro experiments using brain slices, synaptic membrane fraction and brain tissue homogenates. It is shown that the dependence "concentration-effect" is of non-linear character in all cases. Prevailing suppression of Na(+)-dependent uptake and specific receptor binding during K(+)-stimulated release and metabolism (production and utilization) of GABA activation were marked as a general tendency. Mechanisms of TBTO effect on the studied processes and the involvement of GABA-ergic system in realization of TBTO neurotoxic effects are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0028402754&partnerID=8YFLogxK

M3 - статья

C2 - 7998344

AN - SCOPUS:0028402754

VL - 66

SP - 71

EP - 79

JO - Ukrainian biochemical journal

JF - Ukrainian biochemical journal

SN - 2409-4943

IS - 2

ER -