Aim. To elucidate features of hemodynamics in patients with lymphoma and hemodynamic effects of polychemotherapy.

Material and methods. Parameters of central hemodynamics were studied echocardiographycally in 42 patients with lymphoma.

Results. In a definite rise in the levels of tumor progression markers, changes in the immunity, impaired hemopoiesis there was rearrangement of hemodynamics (development of tachycardia, trend to excentric remodeling of the left ventricle). The above changes in hemodynamics enhanced in conduction of polychemotherapy.

Conclusion. To avoid cardiotoxicity of polychemotherapy, lymphoma patients should receive cardioprotectors.