Standard

IsoQuant: a tool for accurate novel isoform discovery with long reads. / Prjibelski , Andrey ; Mikheenko , Alla ; Joglekar, Anoushka; Smetanin, Alexander ; Jarroux, Julien; Lapidus , Alla ; Tilgner, Hagen U.

в: Nature Biotechnology, 26.04.2022.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Prjibelski , A, Mikheenko , A, Joglekar, A, Smetanin, A, Jarroux, J, Lapidus , A & Tilgner, HU 2022, 'IsoQuant: a tool for accurate novel isoform discovery with long reads', Nature Biotechnology. https://doi.org/10.21203/rs.3.rs-1571850/v1

APA

Prjibelski , A., Mikheenko , A., Joglekar, A., Smetanin, A., Jarroux, J., Lapidus , A., & Tilgner, H. U. (2022). IsoQuant: a tool for accurate novel isoform discovery with long reads. Nature Biotechnology. https://doi.org/10.21203/rs.3.rs-1571850/v1

Vancouver

Prjibelski A, Mikheenko A, Joglekar A, Smetanin A, Jarroux J, Lapidus A и пр. IsoQuant: a tool for accurate novel isoform discovery with long reads. Nature Biotechnology. 2022 Апр. 26. https://doi.org/10.21203/rs.3.rs-1571850/v1

Author

Prjibelski , Andrey ; Mikheenko , Alla ; Joglekar, Anoushka ; Smetanin, Alexander ; Jarroux, Julien ; Lapidus , Alla ; Tilgner, Hagen U. / IsoQuant: a tool for accurate novel isoform discovery with long reads. в: Nature Biotechnology. 2022.

BibTeX

@article{0d7e9d2c45bb49e8a23fe47cc6fb96d3,
title = "IsoQuant: a tool for accurate novel isoform discovery with long reads",
abstract = "Long reads are reshaping RNA biology. However, determining alternative isoforms from long-read RNA data is a complex and incompletely solved problem even when the reference genome is known. Here we present IsoQuant - a reference-based tool that accurately discovers novel transcripts with at least 3-fold lower false positive rate and 1.8-fold increase in F1-score compared to other tools for Oxford Nanopore data. IsoQuant also increases performance for Pacific Biosciences data.",
author = "Andrey Prjibelski and Alla Mikheenko and Anoushka Joglekar and Alexander Smetanin and Julien Jarroux and Alla Lapidus and Tilgner, {Hagen U.}",
year = "2022",
month = apr,
day = "26",
doi = "10.21203/rs.3.rs-1571850/v1",
language = "English",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - IsoQuant: a tool for accurate novel isoform discovery with long reads

AU - Prjibelski , Andrey

AU - Mikheenko , Alla

AU - Joglekar, Anoushka

AU - Smetanin, Alexander

AU - Jarroux, Julien

AU - Lapidus , Alla

AU - Tilgner, Hagen U.

PY - 2022/4/26

Y1 - 2022/4/26

N2 - Long reads are reshaping RNA biology. However, determining alternative isoforms from long-read RNA data is a complex and incompletely solved problem even when the reference genome is known. Here we present IsoQuant - a reference-based tool that accurately discovers novel transcripts with at least 3-fold lower false positive rate and 1.8-fold increase in F1-score compared to other tools for Oxford Nanopore data. IsoQuant also increases performance for Pacific Biosciences data.

AB - Long reads are reshaping RNA biology. However, determining alternative isoforms from long-read RNA data is a complex and incompletely solved problem even when the reference genome is known. Here we present IsoQuant - a reference-based tool that accurately discovers novel transcripts with at least 3-fold lower false positive rate and 1.8-fold increase in F1-score compared to other tools for Oxford Nanopore data. IsoQuant also increases performance for Pacific Biosciences data.

UR - https://europepmc.org/article/ppr/ppr486281

UR - https://assets.researchsquare.com/files/rs-1571850/v1_covered.pdf

U2 - 10.21203/rs.3.rs-1571850/v1

DO - 10.21203/rs.3.rs-1571850/v1

M3 - Article

JO - Nature Biotechnology

JF - Nature Biotechnology

SN - 1087-0156

ER -

ID: 100348979