Abstract: This mini review briefly describes (i) literature data on the non-zero current measurements with ionophore-based ion-selective electrodes (ISEs) aimed at fundamental studies of the mechanism of their potentiometric response, and (ii) the data on the possibilities of analytical applications of ISEs in voltametric and constant potential chronoamperometric/coulometric modes, in particular the K ⁺ ion assay in blood serum with the sensitivity of 0.1%. A special attention is paid to the basics of voltammetry and chronoamperometry/coulometry with the ionophore-based ISEs, and to how and why these methods differ from the classical voltammetry and coulometry.