Intraoperative radiation photon therapy (IORT) is a current effective technique based on the radiation exposure of extirpated tumor bed. This method is used in neurosurgery as a part of combined treatment of intracranial malignancies. The article presents the technique, an analysis of surgical treatment of 10 patients with cerebral metastases form of the lung and breast cancer, located in functionally important zones of the brain or nearby. IORT was performed using Carl Zeiss Intrabeam PRS 500(tm) system in combination with preoperative image-guided transcranial motor cortex mapping carried on Nextim NBS. There weren't observed the intraoperative or postoperative complications.