Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Interaction of protonated DNA with trans-dichlorodiammineplatinum(II). / Kasyanenko, N. A.; Prokhorova, S. A.; Haya Enriquez, E. F.; Sudakova, S. S.; Frisman, E. V.; Dyachenko, S. A.; Smorygo, N. A.; Ivin, B. A.
в: Colloids and Surfaces A: Physicochemical and Engineering Aspects, Том 148, № 1-2, 01.03.1999, стр. 121-128.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Interaction of protonated DNA with trans-dichlorodiammineplatinum(II)
AU - Kasyanenko, N. A.
AU - Prokhorova, S. A.
AU - Haya Enriquez, E. F.
AU - Sudakova, S. S.
AU - Frisman, E. V.
AU - Dyachenko, S. A.
AU - Smorygo, N. A.
AU - Ivin, B. A.
N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1999/3/1
Y1 - 1999/3/1
N2 - The optical anisotropy and spectral properties of protonated double-stranded DNA during its interaction with trans-dichlorodiammineplatinum(II) (trans-DDP) have been studied. No changes in the optical anisotropy of protonated DNA macromolecules were observed during the preparation of protonated DNA complexes with trans-DDP. It is known, however, that the binding of trans-DDP to native DNA in solution at neutral pH increases its optical anisotropy. The spectral properties of the complexes under study correspond to those of protonated DNA. The experimental data show that the site of native DNA protonation also plays an important role in its binding to trans-DDP. In contrast, a decrease in the pH of the solution containing trans-DDP-DNA complexes to the value at which DNA protonation takes place does not lead to changes in the optical anisotropy or absorption spectrum of the macromolecule. These facts indicate that the protonation sites on the macromolecule are blocked by trans-DDP. Copyright (C) 1999 Elsevier Science B.V.
AB - The optical anisotropy and spectral properties of protonated double-stranded DNA during its interaction with trans-dichlorodiammineplatinum(II) (trans-DDP) have been studied. No changes in the optical anisotropy of protonated DNA macromolecules were observed during the preparation of protonated DNA complexes with trans-DDP. It is known, however, that the binding of trans-DDP to native DNA in solution at neutral pH increases its optical anisotropy. The spectral properties of the complexes under study correspond to those of protonated DNA. The experimental data show that the site of native DNA protonation also plays an important role in its binding to trans-DDP. In contrast, a decrease in the pH of the solution containing trans-DDP-DNA complexes to the value at which DNA protonation takes place does not lead to changes in the optical anisotropy or absorption spectrum of the macromolecule. These facts indicate that the protonation sites on the macromolecule are blocked by trans-DDP. Copyright (C) 1999 Elsevier Science B.V.
KW - Optical anisotropy of DNA
KW - Protonated DNA
KW - Trans-dichlorodiammineplatinum(II)
UR - http://www.scopus.com/inward/record.url?scp=0033046980&partnerID=8YFLogxK
U2 - 10.1016/S0927-7757(98)00599-8
DO - 10.1016/S0927-7757(98)00599-8
M3 - Article
AN - SCOPUS:0033046980
VL - 148
SP - 121
EP - 128
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
SN - 0927-7757
IS - 1-2
T2 - 8TH INTERNATIONAL SYMPOSIUM ON COLLOIDS AND MOLECULAR ELECTRO-OPTICS
Y2 - 1 June 1997
ER -
ID: 73393197