Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis

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Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis : From Fundamental Biology to Development of New Target-Specific Drugs. / Krasavin, M. Yu.; Gureev, M. A.; Garabadzhiu, A. V.; Pashkin, A. Yu.; Zhukov, A. S.; Khairutdinov, V. R.; Samtsov, A. V.; Shvets, V. I.

в: Doklady Biochemistry and Biophysics, Том 487, № 1, 2019, стр. 272-276.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Krasavin, M. Yu. ; Gureev, M. A. ; Garabadzhiu, A. V. ; Pashkin, A. Yu. ; Zhukov, A. S. ; Khairutdinov, V. R. ; Samtsov, A. V. ; Shvets, V. I. / Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis : From Fundamental Biology to Development of New Target-Specific Drugs. в: Doklady Biochemistry and Biophysics. 2019 ; Том 487, № 1. стр. 272-276.

BibTeX

@article{cc085e69b18947f0b28c06770222d19b,

title = "Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis: From Fundamental Biology to Development of New Target-Specific Drugs",

abstract = "Psoriasis therapy remains an extremely relevant area of modern drug design, due to necessity of adverse reaction reduction, inherent for actual methods of therapy. It was established that two serine proteases-neutrophil elastase 1 (HNE1) and cathepsin G (CatG)-are the key agents in psoriasis development. The collected molecular data for the presented targets form the basis for the molecular modeling strategy for the search for and identification of new target-specific inhibitors. The result of this work is a group of high-priority small-molecule compounds with double-targeted affinity, which are able to suppress the pro-psoriatic processes induced by the considered serine proteases at the initial stage of the disease.",

keywords = "Cathepsin G/antagonists & inhibitors, Drug Discovery, Leukocyte Elastase/antagonists & inhibitors, Models, Molecular, Molecular Targeted Therapy, Protein Conformation, Psoriasis/drug therapy, Serine Proteinase Inhibitors/pharmacology",

author = "Krasavin, {M. Yu.} and Gureev, {M. A.} and Garabadzhiu, {A. V.} and Pashkin, {A. Yu.} and Zhukov, {A. S.} and Khairutdinov, {V. R.} and Samtsov, {A. V.} and Shvets, {V. I.}",

note = "Krasavin, M.Y., Gureev, M.A., Garabadzhiu, A.V. et al. Dokl Biochem Biophys (2019) 487: 272. https://doi.org/10.1134/S1607672919040082",

year = "2019",

doi = "10.1134/S1607672919040082",

language = "English",

volume = "487",

pages = "272--276",

journal = "Doklady Biochemistry and Biophysics",

issn = "1607-6729",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "1",

}

RIS

TY - JOUR

T1 - Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis

T2 - From Fundamental Biology to Development of New Target-Specific Drugs

AU - Krasavin, M. Yu.

AU - Gureev, M. A.

AU - Garabadzhiu, A. V.

AU - Pashkin, A. Yu.

AU - Zhukov, A. S.

AU - Khairutdinov, V. R.

AU - Samtsov, A. V.

AU - Shvets, V. I.

N1 - Krasavin, M.Y., Gureev, M.A., Garabadzhiu, A.V. et al. Dokl Biochem Biophys (2019) 487: 272. https://doi.org/10.1134/S1607672919040082

PY - 2019

Y1 - 2019

N2 - Psoriasis therapy remains an extremely relevant area of modern drug design, due to necessity of adverse reaction reduction, inherent for actual methods of therapy. It was established that two serine proteases-neutrophil elastase 1 (HNE1) and cathepsin G (CatG)-are the key agents in psoriasis development. The collected molecular data for the presented targets form the basis for the molecular modeling strategy for the search for and identification of new target-specific inhibitors. The result of this work is a group of high-priority small-molecule compounds with double-targeted affinity, which are able to suppress the pro-psoriatic processes induced by the considered serine proteases at the initial stage of the disease.

AB - Psoriasis therapy remains an extremely relevant area of modern drug design, due to necessity of adverse reaction reduction, inherent for actual methods of therapy. It was established that two serine proteases-neutrophil elastase 1 (HNE1) and cathepsin G (CatG)-are the key agents in psoriasis development. The collected molecular data for the presented targets form the basis for the molecular modeling strategy for the search for and identification of new target-specific inhibitors. The result of this work is a group of high-priority small-molecule compounds with double-targeted affinity, which are able to suppress the pro-psoriatic processes induced by the considered serine proteases at the initial stage of the disease.

KW - Cathepsin G/antagonists & inhibitors

KW - Drug Discovery

KW - Leukocyte Elastase/antagonists & inhibitors

KW - Models, Molecular

KW - Molecular Targeted Therapy

KW - Protein Conformation

KW - Psoriasis/drug therapy

KW - Serine Proteinase Inhibitors/pharmacology

UR - http://www.scopus.com/inward/record.url?scp=85072708069&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/inhibition-neutrophil-elastase-cathepsin-g-new-approach-treatment-psoriasis-fundamental-biology-deve

U2 - 10.1134/S1607672919040082

DO - 10.1134/S1607672919040082

M3 - Article

C2 - 31559596

AN - SCOPUS:85072708069

VL - 487

SP - 272

EP - 276

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -

ID: 49034318