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Influence of excipients on solubility of oxcarbazepine: Modeling and prediction based on thermodynamic models. / Fan, Qinxi ; Zhang, Mingdong ; Ding, Yewei ; Викторов, Алексей Исмаилович; Ji, Yuanhui.

в: Fluid Phase Equilibria, Том 589, 114251, 01.02.2025.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Fan, Q, Zhang, M, Ding, Y, Викторов, АИ & Ji, Y 2025, 'Influence of excipients on solubility of oxcarbazepine: Modeling and prediction based on thermodynamic models.', Fluid Phase Equilibria, Том. 589, 114251. https://doi.org/10.1016/j.fluid.2024.114251

APA

Fan, Q., Zhang, M., Ding, Y., Викторов, А. И., & Ji, Y. (2025). Influence of excipients on solubility of oxcarbazepine: Modeling and prediction based on thermodynamic models. Fluid Phase Equilibria, 589, [114251]. https://doi.org/10.1016/j.fluid.2024.114251

Vancouver

Fan Q, Zhang M, Ding Y, Викторов АИ, Ji Y. Influence of excipients on solubility of oxcarbazepine: Modeling and prediction based on thermodynamic models. Fluid Phase Equilibria. 2025 Февр. 1;589. 114251. https://doi.org/10.1016/j.fluid.2024.114251

Author

Fan, Qinxi ; Zhang, Mingdong ; Ding, Yewei ; Викторов, Алексей Исмаилович ; Ji, Yuanhui. / Influence of excipients on solubility of oxcarbazepine: Modeling and prediction based on thermodynamic models. в: Fluid Phase Equilibria. 2025 ; Том 589.

BibTeX

@article{88bfb7da9969439583cdc4ae9913955d,
title = "Influence of excipients on solubility of oxcarbazepine: Modeling and prediction based on thermodynamic models.",
abstract = "In this work, the solubility of oxcarbazepine in polymers (PEG 6000, PEG 20000, PVP K25, and PVP K30) and their aqueous solutions was investigated by experimental measurement and thermodynamic modeling. Firstly, the solubility of oxcarbazepine in water and polymers was modeled and the corresponding binary interaction parameters (oxcarbazepine/water and xcarbazepine/polymer) were determined based on the experimental phase equilibrium data. Furthermore, the solubility of oxcarbazepine in the polymer aqueous solution (the mass ratios of polymers in water were 2%, 4%, and 6%) was predicted by the solid-liquid equilibrium (SLE) coupled with the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT). It was observed that the predicted results agreed well with the experimental data, and the average relative deviation (ARD) was less than 7%. In this study, the solubility of oxcarbazepine in polymer aqueous solution was successfully predicted through the SLE coupled with the PC-SAFT, which was expected to provide theoretical guidance for the selection of pharmaceutical excipients and the rational design of preparations.",
keywords = "Oxcarbazepine, Polymers, Solubility, PC-SAFT",
author = "Qinxi Fan and Mingdong Zhang and Yewei Ding and Викторов, {Алексей Исмаилович} and Yuanhui Ji",
year = "2024",
month = oct,
day = "9",
doi = "10.1016/j.fluid.2024.114251",
language = "English",
volume = "589",
journal = "Fluid Phase Equilibria",
issn = "0378-3812",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Influence of excipients on solubility of oxcarbazepine: Modeling and prediction based on thermodynamic models.

AU - Fan, Qinxi

AU - Zhang, Mingdong

AU - Ding, Yewei

AU - Викторов, Алексей Исмаилович

AU - Ji, Yuanhui

PY - 2024/10/9

Y1 - 2024/10/9

N2 - In this work, the solubility of oxcarbazepine in polymers (PEG 6000, PEG 20000, PVP K25, and PVP K30) and their aqueous solutions was investigated by experimental measurement and thermodynamic modeling. Firstly, the solubility of oxcarbazepine in water and polymers was modeled and the corresponding binary interaction parameters (oxcarbazepine/water and xcarbazepine/polymer) were determined based on the experimental phase equilibrium data. Furthermore, the solubility of oxcarbazepine in the polymer aqueous solution (the mass ratios of polymers in water were 2%, 4%, and 6%) was predicted by the solid-liquid equilibrium (SLE) coupled with the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT). It was observed that the predicted results agreed well with the experimental data, and the average relative deviation (ARD) was less than 7%. In this study, the solubility of oxcarbazepine in polymer aqueous solution was successfully predicted through the SLE coupled with the PC-SAFT, which was expected to provide theoretical guidance for the selection of pharmaceutical excipients and the rational design of preparations.

AB - In this work, the solubility of oxcarbazepine in polymers (PEG 6000, PEG 20000, PVP K25, and PVP K30) and their aqueous solutions was investigated by experimental measurement and thermodynamic modeling. Firstly, the solubility of oxcarbazepine in water and polymers was modeled and the corresponding binary interaction parameters (oxcarbazepine/water and xcarbazepine/polymer) were determined based on the experimental phase equilibrium data. Furthermore, the solubility of oxcarbazepine in the polymer aqueous solution (the mass ratios of polymers in water were 2%, 4%, and 6%) was predicted by the solid-liquid equilibrium (SLE) coupled with the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT). It was observed that the predicted results agreed well with the experimental data, and the average relative deviation (ARD) was less than 7%. In this study, the solubility of oxcarbazepine in polymer aqueous solution was successfully predicted through the SLE coupled with the PC-SAFT, which was expected to provide theoretical guidance for the selection of pharmaceutical excipients and the rational design of preparations.

KW - Oxcarbazepine

KW - Polymers

KW - Solubility

KW - PC-SAFT

UR - https://www.mendeley.com/catalogue/badce4d6-92ed-342b-96ef-5d57e7b9afd4/

U2 - 10.1016/j.fluid.2024.114251

DO - 10.1016/j.fluid.2024.114251

M3 - Article

VL - 589

JO - Fluid Phase Equilibria

JF - Fluid Phase Equilibria

SN - 0378-3812

M1 - 114251

ER -

ID: 126150471