Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Inflammatory Cell Infiltration of Adrenals in COVID-19. / Zinserling, Vsevolod A.; Semenova, Natalya Yu.; Markov, Alexander G.; Rybalchenko, Oksana V.; Wang, Jun; Rodionov, Roman N.; Bornstein, Stefan R.
в: Hormone and Metabolic Research, Том 52, № 9, 01.09.2020, стр. 639-641.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Inflammatory Cell Infiltration of Adrenals in COVID-19
AU - Zinserling, Vsevolod A.
AU - Semenova, Natalya Yu.
AU - Markov, Alexander G.
AU - Rybalchenko, Oksana V.
AU - Wang, Jun
AU - Rodionov, Roman N.
AU - Bornstein, Stefan R.
N1 - Funding Information: This work was supported by Transcampus and the Deutsche Forschungsgemeinschaft (GRK 2251/1, TRR 205/1). Publisher Copyright: © 2020 Georg Thieme Verlag. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is expressed not only in the respiratory system, but also in the other organs and systems including adrenal glands. Here we provide the first description of the pathomorphological changes in adrenal glands in patients with severe COVID-19 characterized by perivascular infiltration of CD3+ and CD8+ T-lymphocytes. Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions.
AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is expressed not only in the respiratory system, but also in the other organs and systems including adrenal glands. Here we provide the first description of the pathomorphological changes in adrenal glands in patients with severe COVID-19 characterized by perivascular infiltration of CD3+ and CD8+ T-lymphocytes. Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions.
KW - ACE2
KW - adrenal
KW - COVID-19
KW - infiltrations
KW - SARS-CoV-2
KW - Adrenal Glands/immunology
KW - Pandemics
KW - T-Lymphocytes/immunology
KW - Pneumonia, Viral/immunology
KW - Betacoronavirus/physiology
KW - Humans
KW - Coronavirus Infections/immunology
UR - http://www.scopus.com/inward/record.url?scp=85087879891&partnerID=8YFLogxK
U2 - 10.1055/a-1191-8094
DO - 10.1055/a-1191-8094
M3 - Article
C2 - 32629518
AN - SCOPUS:85087879891
VL - 52
SP - 639
EP - 641
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 9
ER -
ID: 69896065