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Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF3. / Zhouravleva, G. A.; Moskalenko, S. E.; Chabelskaya, S. V.; Philippe, M.; Inge-Vechtomov, S. G.

в: Molecular Biology, Том 40, № 4, 07.2006, стр. 647-653.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

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Author

Zhouravleva, G. A. ; Moskalenko, S. E. ; Chabelskaya, S. V. ; Philippe, M. ; Inge-Vechtomov, S. G. / Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF3. в: Molecular Biology. 2006 ; Том 40, № 4. стр. 647-653.

BibTeX

@article{ec6c6718aa0f4c929bac281b3483a168,
title = "Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF3",
abstract = "We have earlier characterized Saccharomyces cerevisiae strains with mutations of essential SUP45 and SUP35, which code for translation termination factors eRF1 and eRF3, respectively. In this work, the sup45 and sup35 nonsense mutants were compared with respect to the levels of eight tRNAs: tRNA Tyr, tRNAGln, tRNATrp, tRNALeu, tRNAArg (described as potential suppressor tRNAs), tRNA Pro, tRNAHis, and tRNAGly. The mutants did not display a selective increase in tRNAs, capable of a noncanonical read-through at stop codons. Most of the mutations increased the level of all tRNAs under study. The mechanisms providing for the viability of the sup45 and sup35 nonsense mutants are discussed.",
keywords = "eRF1, eRF3, Saccharomyces cerevisiae, Translation termination, tRNA",
author = "Zhouravleva, {G. A.} and Moskalenko, {S. E.} and Chabelskaya, {S. V.} and M. Philippe and Inge-Vechtomov, {S. G.}",
note = "Funding Information: ACKNOWLEDGMENTS This work was supported by the CRDF—Ministry of Education and Science Foundation (project no. ST-012), the Russian Foundation for Basic Research (project no. 03-04-48886), and the program Origin and Evolution of the Biosphere of the Presidium of the Russian Academy of Sciences. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",
year = "2006",
month = jul,
doi = "10.1134/S0026893306040170",
language = "English",
volume = "40",
pages = "647--653",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Pleiades Publishing",
number = "4",

}

RIS

TY - JOUR

T1 - Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF3

AU - Zhouravleva, G. A.

AU - Moskalenko, S. E.

AU - Chabelskaya, S. V.

AU - Philippe, M.

AU - Inge-Vechtomov, S. G.

N1 - Funding Information: ACKNOWLEDGMENTS This work was supported by the CRDF—Ministry of Education and Science Foundation (project no. ST-012), the Russian Foundation for Basic Research (project no. 03-04-48886), and the program Origin and Evolution of the Biosphere of the Presidium of the Russian Academy of Sciences. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/7

Y1 - 2006/7

N2 - We have earlier characterized Saccharomyces cerevisiae strains with mutations of essential SUP45 and SUP35, which code for translation termination factors eRF1 and eRF3, respectively. In this work, the sup45 and sup35 nonsense mutants were compared with respect to the levels of eight tRNAs: tRNA Tyr, tRNAGln, tRNATrp, tRNALeu, tRNAArg (described as potential suppressor tRNAs), tRNA Pro, tRNAHis, and tRNAGly. The mutants did not display a selective increase in tRNAs, capable of a noncanonical read-through at stop codons. Most of the mutations increased the level of all tRNAs under study. The mechanisms providing for the viability of the sup45 and sup35 nonsense mutants are discussed.

AB - We have earlier characterized Saccharomyces cerevisiae strains with mutations of essential SUP45 and SUP35, which code for translation termination factors eRF1 and eRF3, respectively. In this work, the sup45 and sup35 nonsense mutants were compared with respect to the levels of eight tRNAs: tRNA Tyr, tRNAGln, tRNATrp, tRNALeu, tRNAArg (described as potential suppressor tRNAs), tRNA Pro, tRNAHis, and tRNAGly. The mutants did not display a selective increase in tRNAs, capable of a noncanonical read-through at stop codons. Most of the mutations increased the level of all tRNAs under study. The mechanisms providing for the viability of the sup45 and sup35 nonsense mutants are discussed.

KW - eRF1

KW - eRF3

KW - Saccharomyces cerevisiae

KW - Translation termination

KW - tRNA

UR - http://www.scopus.com/inward/record.url?scp=33747124360&partnerID=8YFLogxK

U2 - 10.1134/S0026893306040170

DO - 10.1134/S0026893306040170

M3 - Article

AN - SCOPUS:33747124360

VL - 40

SP - 647

EP - 653

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 4

ER -

ID: 70378862