TY - JOUR

T1 - In vivo voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine in the infralimbic cortex

T2 - Effect of acute ethanol

AU - Deal, Alex L.

AU - Mikhailova, Maria A.

AU - Grinevich, Valentina P.

AU - Weiner, Jeff L.

AU - Gainetdinov, Raul R.

AU - Budygin, Evgeny A.

PY - 2019

Y1 - 2019

N2 - The prefrontal cortex (PFC) plays a critical role in the control of many physiological processes including attention, learning and decision making (Dalley, Cardinal, & Robbins, 2004; Arnsten & Li, 2005; Funahashi & Andreau, 2013). This brain region receives dopamine (DA) and norepinephrine (NE) axons from the ventral tegmental area (VTA) and locus coeruleus (LC), respectively (Waterhouse, Lin, Burne, & Woodward, 1983; Chandler, Lamperski, & Waterhouse, 2013). Therefore, revealing alterations in catecholamine (CA) dynamics in these circuitries is necessary to understand the pathogenesis of different psychiatric diseases, including addiction to drugs and alcohol. Since the PFC is widely involved in complex mental functions, ethanol-induced neuroadaptations can be implicated in impaired cognitive ability and aversive outcomes that facilitate dependence on alcohol. However, changes in cortical CA release under ethanol effects remain unclear. This article is protected by copyright. All rights reserved.

AB - The prefrontal cortex (PFC) plays a critical role in the control of many physiological processes including attention, learning and decision making (Dalley, Cardinal, & Robbins, 2004; Arnsten & Li, 2005; Funahashi & Andreau, 2013). This brain region receives dopamine (DA) and norepinephrine (NE) axons from the ventral tegmental area (VTA) and locus coeruleus (LC), respectively (Waterhouse, Lin, Burne, & Woodward, 1983; Chandler, Lamperski, & Waterhouse, 2013). Therefore, revealing alterations in catecholamine (CA) dynamics in these circuitries is necessary to understand the pathogenesis of different psychiatric diseases, including addiction to drugs and alcohol. Since the PFC is widely involved in complex mental functions, ethanol-induced neuroadaptations can be implicated in impaired cognitive ability and aversive outcomes that facilitate dependence on alcohol. However, changes in cortical CA release under ethanol effects remain unclear. This article is protected by copyright. All rights reserved.

KW - catecholamines

KW - ethanol

KW - locus coeruleus

KW - prefrontal cortex

KW - voltammetry

UR - http://www.scopus.com/inward/record.url?scp=85056809488&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/vivo-voltammetric-evidence-locus-coeruleus-activation-predominantly-releases-norepinephrine-infralim

U2 - 10.1002/syn.22080

DO - 10.1002/syn.22080

M3 - Article

AN - SCOPUS:85056809488

VL - 73

JO - Synapse

JF - Synapse

SN - 0887-4476

IS - 4

M1 - e22080

ER -