TY - JOUR

T1 - In situ decomposition of deep eutectic solvent as a novel approach in liquid-liquid microextraction

AU - Shishov, Andrey

AU - Chromá, Renata

AU - Vakh, Christina

AU - Kuchár, Juraj

AU - Simon, András

AU - Andruch, Vasil

AU - Bulatov, Andrey

PY - 2019/8/13

Y1 - 2019/8/13

N2 - In this study, a novel approach for effective liquid-liquid microextraction based on deep eutectic solvent (DES) decomposition was suggested for the first time. It was established that DESs synthesized from tetrabutylammonium bromide and long-chain alcohols decomposed in aqueous phase resulting in in situ dispersion of organic phase and extraction of hydrophobic analyte(s). It this process long-chain alcohol acted as an extraction solvent and tetrabutylammonium bromide acted as a dispersive agent and promoted mass transfer between aqueous and organic phases as a salting out agent. Phenomenon of DES decomposition was studied in detail and applied for separation and preconcentration in chemical analysis for the first time. The developed approach was applied for 17β-estradiol microextraction from transdermal gel samples as a proof-of-concept example. The results showed that the in situ dispersed organic phase obtained can provide efficient extraction of 17β-estradiol with good extraction recovery (95 ± 5%) and excellent reproducibility (6%). The reported approach proves to be fast, simple, and inexpensive.

AB - In this study, a novel approach for effective liquid-liquid microextraction based on deep eutectic solvent (DES) decomposition was suggested for the first time. It was established that DESs synthesized from tetrabutylammonium bromide and long-chain alcohols decomposed in aqueous phase resulting in in situ dispersion of organic phase and extraction of hydrophobic analyte(s). It this process long-chain alcohol acted as an extraction solvent and tetrabutylammonium bromide acted as a dispersive agent and promoted mass transfer between aqueous and organic phases as a salting out agent. Phenomenon of DES decomposition was studied in detail and applied for separation and preconcentration in chemical analysis for the first time. The developed approach was applied for 17β-estradiol microextraction from transdermal gel samples as a proof-of-concept example. The results showed that the in situ dispersed organic phase obtained can provide efficient extraction of 17β-estradiol with good extraction recovery (95 ± 5%) and excellent reproducibility (6%). The reported approach proves to be fast, simple, and inexpensive.

KW - 17β-estradiol

KW - Deep eutectic solvent

KW - In situ organic phase formation

KW - Liquid-liquid microextraction

KW - 17 beta-estradiol

UR - http://www.scopus.com/inward/record.url?scp=85063350373&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/situ-decomposition-deep-eutectic-solvent-novel-approach-liquidliquid-microextraction

U2 - 10.1016/j.aca.2019.03.038

DO - 10.1016/j.aca.2019.03.038

M3 - Article

AN - SCOPUS:85063350373

VL - 1065

SP - 49

EP - 55

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

SN - 0003-2670

ER -