TY - JOUR

T1 - In Search of Herbal Anti-SARS-Cov2 Compounds

AU - Матвеева, Татьяна Валерьевна

AU - Хафизова, Галина Васильевна

AU - Сокорнова, Софья Валерьевна

N1 - Publisher Copyright: © Copyright © 2020 Matveeva, Khafizova and Sokornova.

PY - 2020/11/16

Y1 - 2020/11/16

N2 - On March 11, 2020, the World Health Organization (WHO) announced that the spread of the new coronavirus had reached the stage of a pandemic. To date (23.10.2020), there are more than 40 million confirmed cases of the disease in the world, at the same time there is still no effective treatment for the disease. For management and treatment of SARS-Cov2, the development of an antiviral drug is needed. Since the representatives of all human cultures have used medicinal plants to treat viral diseases throughout their history, plants can be considered as sources of new antiviral drug compounds against emerging viruses. The huge metabolic potential of plants allows us to expect discovery of plant compounds for the prevention and treatment of coronavirus infection. This idea is supported by number of papers on the anti-SARS-Cov2 activity of plant extracts and specific compounds in the experiments in silico, in vitro, and in vivo. Here, we summarize information on methods and approaches aimed to search for anti-SARS-Cov2 compounds including cheminformatics, bioinformatics, genetic engineering of viral targets, interacting with drugs, biochemical approaches etc. Our mini-review may be useful for better planning future experiments (including rapid methods for screening compounds for antiviral activity, the initial assessment of the antiviral potential of various plant species in relation to certain pathogens, etc.) and giving a hand to those who are making first steps in this field.

AB - On March 11, 2020, the World Health Organization (WHO) announced that the spread of the new coronavirus had reached the stage of a pandemic. To date (23.10.2020), there are more than 40 million confirmed cases of the disease in the world, at the same time there is still no effective treatment for the disease. For management and treatment of SARS-Cov2, the development of an antiviral drug is needed. Since the representatives of all human cultures have used medicinal plants to treat viral diseases throughout their history, plants can be considered as sources of new antiviral drug compounds against emerging viruses. The huge metabolic potential of plants allows us to expect discovery of plant compounds for the prevention and treatment of coronavirus infection. This idea is supported by number of papers on the anti-SARS-Cov2 activity of plant extracts and specific compounds in the experiments in silico, in vitro, and in vivo. Here, we summarize information on methods and approaches aimed to search for anti-SARS-Cov2 compounds including cheminformatics, bioinformatics, genetic engineering of viral targets, interacting with drugs, biochemical approaches etc. Our mini-review may be useful for better planning future experiments (including rapid methods for screening compounds for antiviral activity, the initial assessment of the antiviral potential of various plant species in relation to certain pathogens, etc.) and giving a hand to those who are making first steps in this field.

KW - antiviral drugs

KW - biochemical methods

KW - cheminformatics

KW - coronavirus

KW - genetic engineering

KW - medicinal plants (herbal drugs)

KW - secondary metabolites

KW - NATURAL-PRODUCTS

KW - PAPAIN-LIKE PROTEASE

KW - SARS

KW - CORONAVIRUSES

KW - 3CL(PRO)

KW - EVOLUTION

KW - INHIBITION

KW - DRUGS

KW - INFECTION

KW - MERS

UR - http://www.scopus.com/inward/record.url?scp=85096942498&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/e7b283d6-5ea2-3410-af58-6608366ea47c/

U2 - 10.3389/fpls.2020.589998

DO - 10.3389/fpls.2020.589998

M3 - Review article

C2 - 33304368

VL - 11

JO - Frontiers in Plant Science

JF - Frontiers in Plant Science

SN - 1664-462X

M1 - 589998

ER -