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Impact of biorelevant media on pharmacologically important properties of potential neuroprotectors based on 1,2,4-thiadiazole. / Volkova, Tatyana; Chibunova, Ekaterina; Silyukov, Oleg; Proshin, Alexey; Terekhova, Irina.

в: Journal of Molecular Liquids, Том 247, 2017, стр. 64-69.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Volkova, T, Chibunova, E, Silyukov, O, Proshin, A & Terekhova, I 2017, 'Impact of biorelevant media on pharmacologically important properties of potential neuroprotectors based on 1,2,4-thiadiazole', Journal of Molecular Liquids, Том. 247, стр. 64-69. https://doi.org/10.1016/j.molliq.2017.09.098

APA

Volkova, T., Chibunova, E., Silyukov, O., Proshin, A., & Terekhova, I. (2017). Impact of biorelevant media on pharmacologically important properties of potential neuroprotectors based on 1,2,4-thiadiazole. Journal of Molecular Liquids, 247, 64-69. https://doi.org/10.1016/j.molliq.2017.09.098

Vancouver

Volkova T, Chibunova E, Silyukov O, Proshin A, Terekhova I. Impact of biorelevant media on pharmacologically important properties of potential neuroprotectors based on 1,2,4-thiadiazole. Journal of Molecular Liquids. 2017;247:64-69. https://doi.org/10.1016/j.molliq.2017.09.098

Author

Volkova, Tatyana ; Chibunova, Ekaterina ; Silyukov, Oleg ; Proshin, Alexey ; Terekhova, Irina. / Impact of biorelevant media on pharmacologically important properties of potential neuroprotectors based on 1,2,4-thiadiazole. в: Journal of Molecular Liquids. 2017 ; Том 247. стр. 64-69.

BibTeX

@article{e9d04cbd39554cf8a8a3b7bc4d2f847b,
title = "Impact of biorelevant media on pharmacologically important properties of potential neuroprotectors based on 1,2,4-thiadiazole",
abstract = "Pharmacologically important properties of two structurally related biologically active 1,2,4-thiadiazole derivatives were investigated in phosphate buffer and biorelevant media FaSSIF simulating the intestinal fluid. Solubility and distribution coefficients of thiadiazoles were found to be substantially higher in FaSSIF than in blank buffer. On the contrary, permeability coefficients decreased and dissolution rate was not changed in FaSSIF. Mechanism of FaSSIF components action on thiadiazoles behavior was revealed using 1H NMR and UV-spectroscopy.",
keywords = "1,2,4-Thiadiazole, Biorelevant medium, Dissolution, Distribution, Permeability",
author = "Tatyana Volkova and Ekaterina Chibunova and Oleg Silyukov and Alexey Proshin and Irina Terekhova",
year = "2017",
doi = "10.1016/j.molliq.2017.09.098",
language = "English",
volume = "247",
pages = "64--69",
journal = "Journal of Molecular Liquids",
issn = "0167-7322",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Impact of biorelevant media on pharmacologically important properties of potential neuroprotectors based on 1,2,4-thiadiazole

AU - Volkova, Tatyana

AU - Chibunova, Ekaterina

AU - Silyukov, Oleg

AU - Proshin, Alexey

AU - Terekhova, Irina

PY - 2017

Y1 - 2017

N2 - Pharmacologically important properties of two structurally related biologically active 1,2,4-thiadiazole derivatives were investigated in phosphate buffer and biorelevant media FaSSIF simulating the intestinal fluid. Solubility and distribution coefficients of thiadiazoles were found to be substantially higher in FaSSIF than in blank buffer. On the contrary, permeability coefficients decreased and dissolution rate was not changed in FaSSIF. Mechanism of FaSSIF components action on thiadiazoles behavior was revealed using 1H NMR and UV-spectroscopy.

AB - Pharmacologically important properties of two structurally related biologically active 1,2,4-thiadiazole derivatives were investigated in phosphate buffer and biorelevant media FaSSIF simulating the intestinal fluid. Solubility and distribution coefficients of thiadiazoles were found to be substantially higher in FaSSIF than in blank buffer. On the contrary, permeability coefficients decreased and dissolution rate was not changed in FaSSIF. Mechanism of FaSSIF components action on thiadiazoles behavior was revealed using 1H NMR and UV-spectroscopy.

KW - 1,2,4-Thiadiazole

KW - Biorelevant medium

KW - Dissolution

KW - Distribution

KW - Permeability

UR - http://www.scopus.com/inward/record.url?scp=85030122507&partnerID=8YFLogxK

U2 - 10.1016/j.molliq.2017.09.098

DO - 10.1016/j.molliq.2017.09.098

M3 - Article

AN - SCOPUS:85030122507

VL - 247

SP - 64

EP - 69

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

SN - 0167-7322

ER -

ID: 37016346