TY - JOUR

T1 - Impact of Antithyroperoxidase Antibodies (Anti‐TPO) on Ovarian Reserve and Early Embryo Development in Assisted Reproductive Technology Cycles

AU - Safarian, Galina Kh.

AU - Niauri, Dariko A.

AU - Kogan, Igor Y.

AU - Bespalova, Olesya N.

AU - Dzhemlikhanova, Lyailya Kh.

AU - Lesik, Elena A.

AU - Komarova, Evgeniya M.

AU - Krikheli, Inna O.

AU - Obedkova, Ksenia V.

AU - Tkachenko, Nataliya N.

AU - Milyutina, Yulia P.

AU - Gzgzyan, Aleksandr M.

AU - Shoenfeld, Yehuda

N1 - Safarian, G.K.; Niauri, D.A.; Kogan, I.Y.; Bespalova, O.N.; Dzhemlikhanova, L.K.; Lesik, E.A.; Komarova, E.M.; Krikheli, I.O.; Obedkova, K.V.; Tkachenko, N.N.; Milyutina, Y.P.; Gzgzyan, A.M.; Shoenfeld, Y. Impact of Antithyroperoxidase Antibodies (Anti-TPO) on Ovarian Reserve and Early Embryo Development in Assisted Reproductive Technology Cycles. Int. J. Mol. Sci. 2023, 24, 4705. https://doi.org/10.3390/ijms24054705

PY - 2023/2/28

Y1 - 2023/2/28

N2 - Autoimmune thyroid disease (AITD) is one of the most common endocrinopathies and is more prevalent in women. It becomes evident that the circulating antithyroid antibodies that often follow AITD have effects on many tissues, including ovaries, and therefore that this common morbidity might have an impact on female fertility, the investigation of which is the aim of the present research. Ovarian reserve, ovarian response to stimulation and early embryo development in infertile patients with thyroid autoimmunity were assessed in 45 women with thyroid autoimmunity and 45 age-matched control patients undergoing infertility treatment. It was demonstrated that the presence of anti-thyroid peroxidase antibodies is associated with lower serum anti-Müllerian hormone levels and antral follicle count. Further investigation revealed the higher prevalence of sub-optimal response to ovarian stimulation in TAI-positive women, lower fertilization rate and lower number of high-quality embryos in this group of patients. The cut-off value for follicular fluid anti-thyroid peroxidase antibody affecting the above-mentioned parameters was determined to be 105.0 IU/mL, highlighting the necessity of closer monitoring in couples seeking infertility treatment with ART.

AB - Autoimmune thyroid disease (AITD) is one of the most common endocrinopathies and is more prevalent in women. It becomes evident that the circulating antithyroid antibodies that often follow AITD have effects on many tissues, including ovaries, and therefore that this common morbidity might have an impact on female fertility, the investigation of which is the aim of the present research. Ovarian reserve, ovarian response to stimulation and early embryo development in infertile patients with thyroid autoimmunity were assessed in 45 women with thyroid autoimmunity and 45 age-matched control patients undergoing infertility treatment. It was demonstrated that the presence of anti-thyroid peroxidase antibodies is associated with lower serum anti-Müllerian hormone levels and antral follicle count. Further investigation revealed the higher prevalence of sub-optimal response to ovarian stimulation in TAI-positive women, lower fertilization rate and lower number of high-quality embryos in this group of patients. The cut-off value for follicular fluid anti-thyroid peroxidase antibody affecting the above-mentioned parameters was determined to be 105.0 IU/mL, highlighting the necessity of closer monitoring in couples seeking infertility treatment with ART.

KW - thyroid autoimmunity; infertility; follicular fluid; ovarian reserve; AT-TPO; embryo; IVF

KW - AT-TPO

KW - IVF

KW - embryo

KW - follicular fluid

KW - infertility

KW - ovarian reserve

KW - thyroid autoimmunity

UR - https://www.mendeley.com/catalogue/e2f8479f-70f7-385b-847f-672da6b5cca4/

U2 - 10.3390/ijms24054705

DO - 10.3390/ijms24054705

M3 - Article

C2 - 36902134

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 5

M1 - 4705

ER -