Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
IgSimulator : a versatile immunosequencing simulator. / Safonova, Y.; Lapidus, A.; Lill, J.
в: Bioinformatics, Том 31, № 19, 01.10.2015, стр. 3213-3215.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - IgSimulator
T2 - a versatile immunosequencing simulator
AU - Safonova, Y.
AU - Lapidus, A.
AU - Lill, J.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Motivation: The recent introduction of next-generation sequencing technologies to antibody studies have resulted in a growing number of immunoinformatics tools for antibody repertoire analysis. However, benchmarking these newly emerging tools remains problematic since the gold standard datasets that are needed to validate these tools are typically not available.Results: Since simulating antibody repertoires is often the only feasible way to benchmark new immunoinformatics tools, we developed the IgSimulator tool that addresses various complications in generating realistic antibody repertoires. IgSimulator's code has modular structure and can be easily adapted to new requirements to simulation.
AB - Motivation: The recent introduction of next-generation sequencing technologies to antibody studies have resulted in a growing number of immunoinformatics tools for antibody repertoire analysis. However, benchmarking these newly emerging tools remains problematic since the gold standard datasets that are needed to validate these tools are typically not available.Results: Since simulating antibody repertoires is often the only feasible way to benchmark new immunoinformatics tools, we developed the IgSimulator tool that addresses various complications in generating realistic antibody repertoires. IgSimulator's code has modular structure and can be easily adapted to new requirements to simulation.
U2 - 10.1093/bioinformatics/btv326
DO - 10.1093/bioinformatics/btv326
M3 - статья
VL - 31
SP - 3213
EP - 3215
JO - Bioinformatics
JF - Bioinformatics
SN - 1367-4803
IS - 19
ER -
ID: 5799342