Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Hypothermic versus normothermic cardiopulmonary bypass in patients with valvular heart disease. / Lomivorotov, Vladimir V.; Shmirev, Vladimir A.; Efremov, Sergey M.; Ponomarev, Dmitry N.; Moroz, Gleb B.; Shahin, Denis G.; Kornilov, Igor A.; Shilova, Anna N.; Lomivorotov, Vladimir N.; Karaskov, Alexander M.
в: Journal of Cardiothoracic and Vascular Anesthesia, Том 28, № 2, 01.01.2014, стр. 295-300.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Hypothermic versus normothermic cardiopulmonary bypass in patients with valvular heart disease
AU - Lomivorotov, Vladimir V.
AU - Shmirev, Vladimir A.
AU - Efremov, Sergey M.
AU - Ponomarev, Dmitry N.
AU - Moroz, Gleb B.
AU - Shahin, Denis G.
AU - Kornilov, Igor A.
AU - Shilova, Anna N.
AU - Lomivorotov, Vladimir N.
AU - Karaskov, Alexander M.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Objective The aim of this study was to test the hypothesis that normothermic cardiopulmonary bypass (CPB) is as effective as hypothermic CPB in terms of cardiac protection (cTnI level) and outcome in patients with valvular heart disease. Design Prospective randomized study. Setting A tertiary cardiothoracic referral center. Participants 140 patients who had valvular heart disease, with/without coronary artery disease, surgically treated under CPB. Interventions The patients were allocated randomly to undergo either hypothermic (temperature [T], 31 C-32 C) or normothermic CPB (T>36 C). Measurements and Main Results The primary endpoint was the dynamics of troponin I. The secondary endpoints were ventilation time, the need for inotropic support, intensive care unit (ICU) and hospital stay durations, complications, and mortality. There were no significant intergroup differences in dynamics of troponin I. Ventilation time was significantly lower in the hypothermic group (6 (5-9) and 8 (5-12); p = 0.01). Conclusions Normothermic CPB in patients with valvular heart disease was as effective as hypothermic perfusion in terms of myocardial protection after the surgery assessed by cTnI release. The short ventilation duration in patients who underwent hypothermic CPB needs to be confirmed in a future investigation.
AB - Objective The aim of this study was to test the hypothesis that normothermic cardiopulmonary bypass (CPB) is as effective as hypothermic CPB in terms of cardiac protection (cTnI level) and outcome in patients with valvular heart disease. Design Prospective randomized study. Setting A tertiary cardiothoracic referral center. Participants 140 patients who had valvular heart disease, with/without coronary artery disease, surgically treated under CPB. Interventions The patients were allocated randomly to undergo either hypothermic (temperature [T], 31 C-32 C) or normothermic CPB (T>36 C). Measurements and Main Results The primary endpoint was the dynamics of troponin I. The secondary endpoints were ventilation time, the need for inotropic support, intensive care unit (ICU) and hospital stay durations, complications, and mortality. There were no significant intergroup differences in dynamics of troponin I. Ventilation time was significantly lower in the hypothermic group (6 (5-9) and 8 (5-12); p = 0.01). Conclusions Normothermic CPB in patients with valvular heart disease was as effective as hypothermic perfusion in terms of myocardial protection after the surgery assessed by cTnI release. The short ventilation duration in patients who underwent hypothermic CPB needs to be confirmed in a future investigation.
KW - cardiac protection
KW - cardiac surgery
KW - cardiopulmonary bypass
KW - heart valve disease
KW - hypothermia
KW - normothermia
UR - http://www.scopus.com/inward/record.url?scp=84896390279&partnerID=8YFLogxK
U2 - 10.1053/j.jvca.2013.03.009
DO - 10.1053/j.jvca.2013.03.009
M3 - Article
C2 - 23962460
AN - SCOPUS:84896390279
VL - 28
SP - 295
EP - 300
JO - Journal of Cardiothoracic and Vascular Anesthesia
JF - Journal of Cardiothoracic and Vascular Anesthesia
SN - 1053-0770
IS - 2
ER -
ID: 43524390