TY - JOUR

T1 - Hypothermic versus normothermic cardiopulmonary bypass in patients with valvular heart disease

AU - Lomivorotov, Vladimir V.

AU - Shmirev, Vladimir A.

AU - Efremov, Sergey M.

AU - Ponomarev, Dmitry N.

AU - Moroz, Gleb B.

AU - Shahin, Denis G.

AU - Kornilov, Igor A.

AU - Shilova, Anna N.

AU - Lomivorotov, Vladimir N.

AU - Karaskov, Alexander M.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective The aim of this study was to test the hypothesis that normothermic cardiopulmonary bypass (CPB) is as effective as hypothermic CPB in terms of cardiac protection (cTnI level) and outcome in patients with valvular heart disease. Design Prospective randomized study. Setting A tertiary cardiothoracic referral center. Participants 140 patients who had valvular heart disease, with/without coronary artery disease, surgically treated under CPB. Interventions The patients were allocated randomly to undergo either hypothermic (temperature [T], 31 C-32 C) or normothermic CPB (T>36 C). Measurements and Main Results The primary endpoint was the dynamics of troponin I. The secondary endpoints were ventilation time, the need for inotropic support, intensive care unit (ICU) and hospital stay durations, complications, and mortality. There were no significant intergroup differences in dynamics of troponin I. Ventilation time was significantly lower in the hypothermic group (6 (5-9) and 8 (5-12); p = 0.01). Conclusions Normothermic CPB in patients with valvular heart disease was as effective as hypothermic perfusion in terms of myocardial protection after the surgery assessed by cTnI release. The short ventilation duration in patients who underwent hypothermic CPB needs to be confirmed in a future investigation.

AB - Objective The aim of this study was to test the hypothesis that normothermic cardiopulmonary bypass (CPB) is as effective as hypothermic CPB in terms of cardiac protection (cTnI level) and outcome in patients with valvular heart disease. Design Prospective randomized study. Setting A tertiary cardiothoracic referral center. Participants 140 patients who had valvular heart disease, with/without coronary artery disease, surgically treated under CPB. Interventions The patients were allocated randomly to undergo either hypothermic (temperature [T], 31 C-32 C) or normothermic CPB (T>36 C). Measurements and Main Results The primary endpoint was the dynamics of troponin I. The secondary endpoints were ventilation time, the need for inotropic support, intensive care unit (ICU) and hospital stay durations, complications, and mortality. There were no significant intergroup differences in dynamics of troponin I. Ventilation time was significantly lower in the hypothermic group (6 (5-9) and 8 (5-12); p = 0.01). Conclusions Normothermic CPB in patients with valvular heart disease was as effective as hypothermic perfusion in terms of myocardial protection after the surgery assessed by cTnI release. The short ventilation duration in patients who underwent hypothermic CPB needs to be confirmed in a future investigation.

KW - cardiac protection

KW - cardiac surgery

KW - cardiopulmonary bypass

KW - heart valve disease

KW - hypothermia

KW - normothermia

UR - http://www.scopus.com/inward/record.url?scp=84896390279&partnerID=8YFLogxK

U2 - 10.1053/j.jvca.2013.03.009

DO - 10.1053/j.jvca.2013.03.009

M3 - Article

C2 - 23962460

AN - SCOPUS:84896390279

VL - 28

SP - 295

EP - 300

JO - Journal of Cardiothoracic and Vascular Anesthesia

JF - Journal of Cardiothoracic and Vascular Anesthesia

SN - 1053-0770

IS - 2

ER -