TY - JOUR

T1 - Hyperhomocysteinemia in men with metabolic syndrome and early stages of chronic kidney disease

AU - Hudiakova, N. V.

AU - Pchelin, I. Y.

AU - Shishkin, A. N.

AU - Smirnov, V. V.

AU - Ivanov, N. V.

AU - Makarenko, M. V.

AU - Bayrasheva, V. K.

AU - Staroselsky, K. G.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective. We investigated homocysteine metabolism in men with early stages of chronic kidney disease (CKD) and metabolic syndrome (MS). Design and methods. A total of 79 men were selected and divided into two groups, i. e. CKD C1-C2 degree and MS with abnormal carbohydrate metabolism (main group, n = 44) and CKD C1-C2 degree and MS with normal carbohydrate metabolism (control group, n = 35). We assessed serum levels of fasting and postprandial glucose, HbA1c, insulin, C-peptide, homocysteine. We also studied polymorphisms of the genes encoding homocysteine metabolism-related enzymes. Results. 82,3 % patients had elevated serum levels of homocysteine with no significant differences between the groups. 90,0 % cases of hyperhomocysteinemia (HHC) in men with CKD C1-C2 degree and MS were associated with polymorphism of the genes encoding homocysteine metabolism-related enzymes. In men with CKD C1-C2 degree and MS with normal carbohydrate metabolism we found positive correlations between creatinine and homocysteine (rs = 0,4; p < 0,05). Conclusions. The majority of men with MS and CKD C1-C2 degree have hyperhomocysteinemia that is usually determined by genetic factors. Serum level of homocysteine at the initial stages of renal dysfunction does not depend on the state of carbohydrate metabolism in MS.

AB - Objective. We investigated homocysteine metabolism in men with early stages of chronic kidney disease (CKD) and metabolic syndrome (MS). Design and methods. A total of 79 men were selected and divided into two groups, i. e. CKD C1-C2 degree and MS with abnormal carbohydrate metabolism (main group, n = 44) and CKD C1-C2 degree and MS with normal carbohydrate metabolism (control group, n = 35). We assessed serum levels of fasting and postprandial glucose, HbA1c, insulin, C-peptide, homocysteine. We also studied polymorphisms of the genes encoding homocysteine metabolism-related enzymes. Results. 82,3 % patients had elevated serum levels of homocysteine with no significant differences between the groups. 90,0 % cases of hyperhomocysteinemia (HHC) in men with CKD C1-C2 degree and MS were associated with polymorphism of the genes encoding homocysteine metabolism-related enzymes. In men with CKD C1-C2 degree and MS with normal carbohydrate metabolism we found positive correlations between creatinine and homocysteine (rs = 0,4; p < 0,05). Conclusions. The majority of men with MS and CKD C1-C2 degree have hyperhomocysteinemia that is usually determined by genetic factors. Serum level of homocysteine at the initial stages of renal dysfunction does not depend on the state of carbohydrate metabolism in MS.

KW - Chronic kidney disease

KW - Hyperhomocysteinemia

KW - Metabolic syndrome

KW - MTHFR (EC 1.5.1.20)

KW - MTR (EC 2.1.1.13)

KW - Polymorphisms of genes of MTRR (EC 1.16.1.8)

UR - http://www.scopus.com/inward/record.url?scp=85019671497&partnerID=8YFLogxK

U2 - 10.18705/1607-419X-2017-23-2-141-149

DO - 10.18705/1607-419X-2017-23-2-141-149

M3 - Article

AN - SCOPUS:85019671497

VL - 23

SP - 141

EP - 149

JO - Arterial Hypertension (Russian Federation)

JF - Arterial Hypertension (Russian Federation)

SN - 1607-419X

IS - 2

ER -