TY - JOUR

T1 - Human accelerated regions and other human-specific sequence variations in the context of evolution and their relevance for brain development

AU - Levchenko, Anastasia

AU - Kanapin, Alexander

AU - Samsonova, Anastasia

AU - Gainetdinov, Raul R.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The review discusses, in a format of a timeline, the studies of different types of genetic variants, present in Homo sapiens, but absent in all other primate, mammalian, or vertebrate species, tested so far. The main characteristic of these variants is that they are found in regions of high evolutionary conservation. These sequence variations include single nucleotide substitutions (called human accelerated regions), deletions, and segmental duplications. The rationale for finding such variations in the human genome is that they could be responsible for traits, specific to our species, of which the human brain is the most remarkable. As became obvious, the vast majority of human-specific single nucleotide substitutions are found in noncoding, likely regulatory regions. A number of genes, associated with these human-specific alleles, often through novel enhancer activity, were in fact shown to be implicated in human-specific development of certain brain areas, including the prefrontal cortex. Human-specific deletions may remove regulatory sequences, such as enhancers. Segmental duplications, because of their large size, create new coding sequences, like new functional paralogs. Further functional study of these variants will shed light on evolution of our species, as well as on the etiology of neurodevelopmental disorders.

AB - The review discusses, in a format of a timeline, the studies of different types of genetic variants, present in Homo sapiens, but absent in all other primate, mammalian, or vertebrate species, tested so far. The main characteristic of these variants is that they are found in regions of high evolutionary conservation. These sequence variations include single nucleotide substitutions (called human accelerated regions), deletions, and segmental duplications. The rationale for finding such variations in the human genome is that they could be responsible for traits, specific to our species, of which the human brain is the most remarkable. As became obvious, the vast majority of human-specific single nucleotide substitutions are found in noncoding, likely regulatory regions. A number of genes, associated with these human-specific alleles, often through novel enhancer activity, were in fact shown to be implicated in human-specific development of certain brain areas, including the prefrontal cortex. Human-specific deletions may remove regulatory sequences, such as enhancers. Segmental duplications, because of their large size, create new coding sequences, like new functional paralogs. Further functional study of these variants will shed light on evolution of our species, as well as on the etiology of neurodevelopmental disorders.

KW - Deletions

KW - Duplications

KW - Genes

KW - Neurodevelopmental disorders

KW - Psychiatry

KW - Substitutions

KW - Humans

KW - Regulatory Sequences, Nucleic Acid

KW - Brain/growth & development

KW - Genetic Variation

KW - Animals

KW - Base Sequence

KW - Genome, Human

KW - Evolution, Molecular

UR - http://www.scopus.com/inward/record.url?scp=85044351504&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/human-accelerated-regions-other-humanspecific-sequence-variations-context-evolution-relevance-brain

U2 - 10.1093/gbe/evx240

DO - 10.1093/gbe/evx240

M3 - Review article

AN - SCOPUS:85044351504

VL - 10

SP - 166

EP - 188

JO - Genome Biology and Evolution

JF - Genome Biology and Evolution

SN - 1759-6653

IS - 1

ER -