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Hidden symmetries of DNA molecule. / Tulub, Alexander A.; Stefanov, Vassily E.
в: Journal of Theoretical Biology, Том 416, 07.03.2017, стр. 144-148.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Hidden symmetries of DNA molecule
AU - Tulub, Alexander A.
AU - Stefanov, Vassily E.
N1 - Publisher Copyright: © 2017 Elsevier Ltd
PY - 2017/3/7
Y1 - 2017/3/7
N2 - Despite the fact that DNA molecule is studied up and down, we know very little about the role of DNA triplets in coding amino acids and stop-codons. The paper aims to fill this gap through attracting spintronic ideas and carrying out QM/MM computations on a full-turn DNA fragment. The computations reveal two hidden symmetries: the spin splitting (the Rashba effect), confined within each triplet, and the quantum “phase” link between the triplet nature (in total, 64 triplets) and the corresponding amino acid and three stop-codons. The hidden symmetries become evident upon binding the magnesium cofactor to DNA triplets in 5’−3’ and 3’−5’ directions.
AB - Despite the fact that DNA molecule is studied up and down, we know very little about the role of DNA triplets in coding amino acids and stop-codons. The paper aims to fill this gap through attracting spintronic ideas and carrying out QM/MM computations on a full-turn DNA fragment. The computations reveal two hidden symmetries: the spin splitting (the Rashba effect), confined within each triplet, and the quantum “phase” link between the triplet nature (in total, 64 triplets) and the corresponding amino acid and three stop-codons. The hidden symmetries become evident upon binding the magnesium cofactor to DNA triplets in 5’−3’ and 3’−5’ directions.
KW - DNA molecule
KW - Genetic code
KW - Hidden symmetries
KW - Nucleotide triplets
KW - QM/MM computations
KW - Spin physics
UR - http://www.scopus.com/inward/record.url?scp=85009363512&partnerID=8YFLogxK
U2 - 10.1016/j.jtbi.2017.01.001
DO - 10.1016/j.jtbi.2017.01.001
M3 - Article
C2 - 28077290
VL - 416
SP - 144
EP - 148
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
ER -
ID: 7734131