TY - JOUR

T1 - Heteromolecular compounds in binary systems of amino acids with opposite and same chiralities

AU - Isakov, Anton I.

AU - Lorenz, Heike

AU - Zolotarev, Andrey A.

AU - Kotelnikova, Elena N.

PY - 2020/2/7

Y1 - 2020/2/7

N2 - A classification of discrete compounds in binary chiral systems of single and different substances (homo- A nd heteromolecular compounds) is presented. It considers both chemical and crystallographic characteristics of such compounds. Using amino acids as chiral model systems, features of crystal structures of equimolar and non-equimolar heteromolecular compounds are reviewed. In this connection, the concept of homo- A nd heteromolecular dimers in compounds formed by amino acids is introduced and analyzed. As a result, a correlation between the molecular dimer type and the side chain structure (linear or branched) and the conformation (extended or folded) of the relevant compounds' molecules is derived. Two non-equimolar discrete heterocompounds discovered in the chiral systems l-valine-l-isoleucine and l-valine-l-leucine are discussed using the concepts proposed. The previously studied first system features a 2:1 (Val:Ile) compound. A newly investigated second system is found to form a 3:1 (Val:Leu) compound, and its crystal structure is described and evaluated.

AB - A classification of discrete compounds in binary chiral systems of single and different substances (homo- A nd heteromolecular compounds) is presented. It considers both chemical and crystallographic characteristics of such compounds. Using amino acids as chiral model systems, features of crystal structures of equimolar and non-equimolar heteromolecular compounds are reviewed. In this connection, the concept of homo- A nd heteromolecular dimers in compounds formed by amino acids is introduced and analyzed. As a result, a correlation between the molecular dimer type and the side chain structure (linear or branched) and the conformation (extended or folded) of the relevant compounds' molecules is derived. Two non-equimolar discrete heterocompounds discovered in the chiral systems l-valine-l-isoleucine and l-valine-l-leucine are discussed using the concepts proposed. The previously studied first system features a 2:1 (Val:Ile) compound. A newly investigated second system is found to form a 3:1 (Val:Leu) compound, and its crystal structure is described and evaluated.

UR - http://www.scopus.com/inward/record.url?scp=85078979424&partnerID=8YFLogxK

U2 - 10.1039/c9ce01333d

DO - 10.1039/c9ce01333d

M3 - Article

AN - SCOPUS:85078979424

VL - 22

SP - 986

EP - 997

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 5

ER -