Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents

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Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents. / Krasavin, Mikhail ; Shetnev, Anton; Panova, Valeria; Ivanovskyi, Sergey; Kalinin, Stanislav ; Vinogradova, Tatiana ; Sharoyko, Vladimir; Yablonsky, Piotr.

в: Mendeleev Communications , Том 32, № 4, 01.07.2022, стр. 452-453.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{9602d824c22746079aa3680b0bbe28b5,

title = "Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents",

abstract = "New (E)-5-[2-(5-nitrofuran-2-yl)vinyl]-1,2,4-oxadiazoles and 5-(5-nitrofuran-2-yl)-1,2,4-oxadiazoles were synthesized via the base-promoted condensation of nitrofuran-containing acyl chlorides with amidoximes. Testing these compounds against Gram-negative E. coli, Gram-positive B. subtilis and S. aureus as well as M. tuberculosis HRv37 strain revealed three compounds being selectively antimycobacterial. None of these compounds displayed any cytotoxicity towards human pancreatic epithelioid carcinoma cell line, PANC-1.",

keywords = "124-oxadiazoles, amidoximes, antibacterial assay, antimycobacterial assay, cell viability, direct bond, MTT assay, nitrofurans, olefin linker",

author = "Mikhail Krasavin and Anton Shetnev and Valeria Panova and Sergey Ivanovskyi and Stanislav Kalinin and Tatiana Vinogradova and Vladimir Sharoyko and Piotr Yablonsky",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = jul,

day = "1",

doi = "10.1016/j.mencom.2022.07.008",

language = "English",

volume = "32",

pages = "452--453",

journal = "Mendeleev Communications",

issn = "0959-9436",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents

AU - Krasavin, Mikhail

AU - Shetnev, Anton

AU - Panova, Valeria

AU - Ivanovskyi, Sergey

AU - Kalinin, Stanislav

AU - Vinogradova, Tatiana

AU - Sharoyko, Vladimir

AU - Yablonsky, Piotr

PY - 2022/7/1

Y1 - 2022/7/1

N2 - New (E)-5-[2-(5-nitrofuran-2-yl)vinyl]-1,2,4-oxadiazoles and 5-(5-nitrofuran-2-yl)-1,2,4-oxadiazoles were synthesized via the base-promoted condensation of nitrofuran-containing acyl chlorides with amidoximes. Testing these compounds against Gram-negative E. coli, Gram-positive B. subtilis and S. aureus as well as M. tuberculosis HRv37 strain revealed three compounds being selectively antimycobacterial. None of these compounds displayed any cytotoxicity towards human pancreatic epithelioid carcinoma cell line, PANC-1.

AB - New (E)-5-[2-(5-nitrofuran-2-yl)vinyl]-1,2,4-oxadiazoles and 5-(5-nitrofuran-2-yl)-1,2,4-oxadiazoles were synthesized via the base-promoted condensation of nitrofuran-containing acyl chlorides with amidoximes. Testing these compounds against Gram-negative E. coli, Gram-positive B. subtilis and S. aureus as well as M. tuberculosis HRv37 strain revealed three compounds being selectively antimycobacterial. None of these compounds displayed any cytotoxicity towards human pancreatic epithelioid carcinoma cell line, PANC-1.

KW - 124-oxadiazoles

KW - amidoximes

KW - antibacterial assay

KW - antimycobacterial assay

KW - cell viability

KW - direct bond

KW - MTT assay

KW - nitrofurans

KW - olefin linker

UR - http://www.scopus.com/inward/record.url?scp=85135416795&partnerID=8YFLogxK

U2 - 10.1016/j.mencom.2022.07.008

DO - 10.1016/j.mencom.2022.07.008

M3 - Article

AN - SCOPUS:85135416795

VL - 32

SP - 452

EP - 453

JO - Mendeleev Communications

JF - Mendeleev Communications

SN - 0959-9436

IS - 4

ER -

ID: 97843500