Abstract—We present the study of the multiple system HD 52721 by means of speckle interferometry in 2019–2020 at the 6-m telescope of the SAO RAS. Formerly, HD 52721 was known as triple (Formula presented.). In our work, the system is resolved as a speckle interferometric triple system, i.e., the total system multiplicity increased up to four components (Formula presented.). We have used the reference-dependent and reference-independent methods for measuring positional parameters and magnitude differences between the components. The obtained measurements of the brightness differences agree with the observed light curve of the eclipsing pair.