DOI

This work presents a method for covalent functionalization of GO with a cytostatic preparation DOX with a loading of 87 %. The resulting nanomaterial was characterized using modern physicochemical methods (13C NMR, Raman, IR, UV/Vis spectroscopy, XPS, XRD, HRTEM). The synthesized conjugate showed significant antiaggregating activity and selective cytotoxicity towards the A549 cell line, significantly superior to individual DOX, as well as low cytotoxicity towards the non-cancer cell line HEK293. The complex biocompatibility study was conducted for the synthesized conjugate including hemocompatibility study, antioxidant activity, interaction with HSA and DNA, geno- and cytotoxicity investigation. At the same time, molecular dynamics investigation was performed in order to determine the features of intermolecular interaction between GO and DOX molecules.

Язык оригиналаанглийский
Номер статьи119156
ЖурналJournal of Molecular Liquids
Том359
DOI
СостояниеОпубликовано - 1 авг 2022

    Предметные области Scopus

  • Электроника, оптика и магнитные материалы
  • Атомная и молекулярная физика и оптика
  • Физика конденсатов
  • Спектроскопия
  • Физическая и теоретическая химия
  • Химия материалов

ID: 96220132