Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids. / Гладнев, Сергей Владиславович; Левит, М. Л.; Тенникова, Татьяна Борисовна; Коржикова-Влах, Евгения Георгиевна.
в: Mendeleev Communications, Том 35, № 3, 01.01.2025, стр. 295-298.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Glycopolymer-graft-polypeptide copolymers as potential carriers for nucleic acids.
AU - Гладнев, Сергей Владиславович
AU - Левит, М. Л.
AU - Тенникова, Татьяна Борисовна
AU - Коржикова-Влах, Евгения Георгиевна
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Bioinspired copolymers consisting of a glycopolymer main chain grafted with polylysine were synthesized using metal-free click chemistry based on a 1,3-dipolar cycloaddition reaction involving strained cyclic alkyne. Poly(2-deoxy-2-methacrylamido-d-glucose)-graft-polylysine was efficiently complexed with a double-stranded oligonucleotide duplex. The cytotoxicity of the polyplex was lower than that of the free copolymer.
AB - Bioinspired copolymers consisting of a glycopolymer main chain grafted with polylysine were synthesized using metal-free click chemistry based on a 1,3-dipolar cycloaddition reaction involving strained cyclic alkyne. Poly(2-deoxy-2-methacrylamido-d-glucose)-graft-polylysine was efficiently complexed with a double-stranded oligonucleotide duplex. The cytotoxicity of the polyplex was lower than that of the free copolymer.
KW - bioinspired copolymers
KW - delivery systems
KW - graft copolymers
KW - metal-free click chemistry
KW - nucleic acids
KW - polypeptides
KW - synthetic glycopolymers
UR - https://www.mendeley.com/catalogue/f1b82804-fa06-3965-b066-0e61ee04906e/
U2 - 10.71267/mencom.7606
DO - 10.71267/mencom.7606
M3 - Article
VL - 35
SP - 295
EP - 298
JO - Mendeleev Communications
JF - Mendeleev Communications
SN - 0959-9436
IS - 3
ER -
ID: 134067433