TY - JOUR

T1 - Giant reticulospinal synapse in lamprey

T2 - Molecular links between active and periactive zones

AU - Brodin, Lennart

AU - Shupliakov, Oleg

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Deciphering the function of synaptic release sites is central to understanding neuronal communication. Here, we review studies of the lamprey giant reticulospinal synapse, a model that can be used to dissect synaptic vesicle trafficking at single release sites. The presynaptic axon is large and contains active zones that are spatially separated from each other. During activity, synaptic vesicle membrane is shuttled between the active zone and the periactive zone at which endocytosis occurs. Recent studies have shown that the periactive zone contains an actin-rich cytomatrix that expands during synaptic activity. This cytomatrix has been implicated in multiple functions that include (1) activity-dependent trafficking of proteins between the synaptic vesicle cluster and the periactive zone, (2) synaptic vesicle endocytosis, and (3) the movement of newly formed synaptic vesicles to the vesicle cluster. The actin cytomatrix thus provides a link between the active zone and the periactive zone; this link appears to be critical for sustained cycling of synaptic vesicles.

AB - Deciphering the function of synaptic release sites is central to understanding neuronal communication. Here, we review studies of the lamprey giant reticulospinal synapse, a model that can be used to dissect synaptic vesicle trafficking at single release sites. The presynaptic axon is large and contains active zones that are spatially separated from each other. During activity, synaptic vesicle membrane is shuttled between the active zone and the periactive zone at which endocytosis occurs. Recent studies have shown that the periactive zone contains an actin-rich cytomatrix that expands during synaptic activity. This cytomatrix has been implicated in multiple functions that include (1) activity-dependent trafficking of proteins between the synaptic vesicle cluster and the periactive zone, (2) synaptic vesicle endocytosis, and (3) the movement of newly formed synaptic vesicles to the vesicle cluster. The actin cytomatrix thus provides a link between the active zone and the periactive zone; this link appears to be critical for sustained cycling of synaptic vesicles.

KW - Actin

KW - Active zone

KW - Endocytosis

KW - Exocytosis

KW - Lamprey

KW - Synaptic vesicle

UR - http://www.scopus.com/inward/record.url?scp=33748935567&partnerID=8YFLogxK

U2 - 10.1007/s00441-006-0216-2

DO - 10.1007/s00441-006-0216-2

M3 - Review article

C2 - 16786368

AN - SCOPUS:33748935567

VL - 326

SP - 301

EP - 310

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

IS - 2

ER -