Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population

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Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population. / Shevchenko, Andrey K. ; Zhernakova, Daria V. ; Малов, Сергей Васильевич ; Комиссаров, Алексей Сергеевич; Колчанова, София Михайловна; Тамазян, Гайк Симакович ; Антоник, Алексей Вадимович; Черкасов, Николай Андреевич; Кливер, Сергей Федорович ; Туренко, Анастасия Сергеевна; Роткевич, Михаил Сергеевич; Евсюков, Игорь Валерьевич; Vlahov, David ; Thami, Prisca K. ; Gaseitsiwe, Simani ; Novitsky, Vladimir ; О Брайен, Стефан Джеймс; Essex, Myron .

в: Proceedings of the National Academy of Sciences of the United States of America, Том 118, № 47, e2107830118, 23.11.2021.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{7ee3e8cc2cbf47359125425d6b0b5810,

title = "Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population",

abstract = "Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, which have the highest density of HIV infections worldwide. We carried out genome-wide association studies on 766 study participants at risk for HIV-1 subtype C (HIV-1C) infection in Botswana. Three gene associations (AP3B1, PTPRA, and NEO1) were shown to have significant association with HIV-1C acquisition. Each gene association was replicated within Botswana or in the United States-African American or United States-European American AIDS cohorts or in both. Each associated gene has a prior reported influence on HIV/ AIDS pathogenesis. Thirteen previously discovered AIDS restriction genes were further replicated in the Botswana cohorts, extending our confidence in these prior AIDS restriction gene reports. This work presents an early step toward the identification of genetic variants associated with and affecting HIV acquisition or AIDS progression in the understudied HIV-1C afflicted Botswana population.",

keywords = "AIDS, Botswana, GWAS, GWATCH, HIV-C, Genome-Wide Association Study, Botswana/epidemiology, Humans, Genotype, Adaptor Protein Complex beta Subunits/genetics, Genetic Variation, Receptors, Cell Surface/genetics, Acquired Immunodeficiency Syndrome, Nerve Tissue Proteins/genetics, Receptor-Like Protein Tyrosine Phosphatases, Class 4/genetics, HIV Infections/epidemiology, Adaptor Protein Complex 3/genetics, VIRAL LOAD, SUSCEPTIBILITY, SUBTYPE-C INFECTION, RNA LEVELS, T-CELL RESPONSES, MUTATIONS, GAG, IDENTIFICATION, HERMANSKY-PUDLAK-SYNDROME, DISEASE PROGRESSION",

author = "Shevchenko, {Andrey K.} and Zhernakova, {Daria V.} and Малов, {Сергей Васильевич} and Комиссаров, {Алексей Сергеевич} and Колчанова, {София Михайловна} and Тамазян, {Гайк Симакович} and Антоник, {Алексей Вадимович} and Черкасов, {Николай Андреевич} and Кливер, {Сергей Федорович} and Туренко, {Анастасия Сергеевна} and Роткевич, {Михаил Сергеевич} and Евсюков, {Игорь Валерьевич} and David Vlahov and Thami, {Prisca K.} and Simani Gaseitsiwe and Vladimir Novitsky and {О Брайен}, {Стефан Джеймс} and Myron Essex",

year = "2021",

month = nov,

day = "23",

doi = "10.1073/pnas.2107830118",

language = "English",

volume = "118",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "47",

}

RIS

TY - JOUR

T1 - Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population

AU - Shevchenko, Andrey K.

AU - Zhernakova, Daria V.

AU - Малов, Сергей Васильевич

AU - Комиссаров, Алексей Сергеевич

AU - Колчанова, София Михайловна

AU - Тамазян, Гайк Симакович

AU - Антоник, Алексей Вадимович

AU - Черкасов, Николай Андреевич

AU - Кливер, Сергей Федорович

AU - Туренко, Анастасия Сергеевна

AU - Роткевич, Михаил Сергеевич

AU - Евсюков, Игорь Валерьевич

AU - Vlahov, David

AU - Thami, Prisca K.

AU - Gaseitsiwe, Simani

AU - Novitsky, Vladimir

AU - О Брайен, Стефан Джеймс

AU - Essex, Myron

PY - 2021/11/23

Y1 - 2021/11/23

N2 - Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, which have the highest density of HIV infections worldwide. We carried out genome-wide association studies on 766 study participants at risk for HIV-1 subtype C (HIV-1C) infection in Botswana. Three gene associations (AP3B1, PTPRA, and NEO1) were shown to have significant association with HIV-1C acquisition. Each gene association was replicated within Botswana or in the United States-African American or United States-European American AIDS cohorts or in both. Each associated gene has a prior reported influence on HIV/ AIDS pathogenesis. Thirteen previously discovered AIDS restriction genes were further replicated in the Botswana cohorts, extending our confidence in these prior AIDS restriction gene reports. This work presents an early step toward the identification of genetic variants associated with and affecting HIV acquisition or AIDS progression in the understudied HIV-1C afflicted Botswana population.

AB - Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, which have the highest density of HIV infections worldwide. We carried out genome-wide association studies on 766 study participants at risk for HIV-1 subtype C (HIV-1C) infection in Botswana. Three gene associations (AP3B1, PTPRA, and NEO1) were shown to have significant association with HIV-1C acquisition. Each gene association was replicated within Botswana or in the United States-African American or United States-European American AIDS cohorts or in both. Each associated gene has a prior reported influence on HIV/ AIDS pathogenesis. Thirteen previously discovered AIDS restriction genes were further replicated in the Botswana cohorts, extending our confidence in these prior AIDS restriction gene reports. This work presents an early step toward the identification of genetic variants associated with and affecting HIV acquisition or AIDS progression in the understudied HIV-1C afflicted Botswana population.

KW - AIDS

KW - Botswana

KW - GWAS

KW - GWATCH

KW - HIV-C

KW - Genome-Wide Association Study

KW - Botswana/epidemiology

KW - Humans

KW - Genotype

KW - Adaptor Protein Complex beta Subunits/genetics

KW - Genetic Variation

KW - Receptors, Cell Surface/genetics

KW - Acquired Immunodeficiency Syndrome

KW - Nerve Tissue Proteins/genetics

KW - Receptor-Like Protein Tyrosine Phosphatases, Class 4/genetics

KW - HIV Infections/epidemiology

KW - Adaptor Protein Complex 3/genetics

KW - VIRAL LOAD

KW - SUSCEPTIBILITY

KW - SUBTYPE-C INFECTION

KW - RNA LEVELS

KW - T-CELL RESPONSES

KW - MUTATIONS

KW - GAG

KW - IDENTIFICATION

KW - HERMANSKY-PUDLAK-SYNDROME

KW - DISEASE PROGRESSION

UR - http://www.scopus.com/inward/record.url?scp=85120307285&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/8dc32987-5d45-3e4b-a7ea-2bc34a93d425/

U2 - 10.1073/pnas.2107830118

DO - 10.1073/pnas.2107830118

M3 - Article

C2 - 34782459

VL - 118

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 47

M1 - e2107830118

ER -

ID: 88675348