Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis. / Sorokin, Alexei; Anderson, Iain; Galleron, Nathalie; Candelon, Benjamin; Kapatral, Vinayak; Bhattacharyya, Anamitra; Reznik, Gary; Lapidus, Alla; Chu, Lien; Mazur, Michael; Goltsman, Eugene; Larsen, Niels; D'Souza, Mark; Walunas, Theresa; Grechkin, Yuri; Pusch, Gordon; Haselkorn, Robert; Fonstein, Michael; Ehrlich, S. Dusko; Overbeek, Ross; Kyrpides, Nikos.
в: Nature, Том 423, № 6935, 2003, стр. 87-91.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis
AU - Sorokin, Alexei
AU - Anderson, Iain
AU - Galleron, Nathalie
AU - Candelon, Benjamin
AU - Kapatral, Vinayak
AU - Bhattacharyya, Anamitra
AU - Reznik, Gary
AU - Lapidus, Alla
AU - Chu, Lien
AU - Mazur, Michael
AU - Goltsman, Eugene
AU - Larsen, Niels
AU - D'Souza, Mark
AU - Walunas, Theresa
AU - Grechkin, Yuri
AU - Pusch, Gordon
AU - Haselkorn, Robert
AU - Fonstein, Michael
AU - Ehrlich, S. Dusko
AU - Overbeek, Ross
AU - Kyrpides, Nikos
N1 - Funding Information: Acknowledgements This Letter is dedicated to the memory of our dear colleagues M. Mazur and C. Anagnostopoulos. This work was supported by a DARPA STTR grant to Integrated Genomics Inc.
PY - 2003
Y1 - 2003
N2 - Bacillus cereus is an opportunistic pathogen causing food poisoning manifested by diarrhoeal or emetic syndromes. It is closely related to the animal and human pathogen Bacillus anthracis and the insect pathogen Bacillus thuringiensis, the former being used as a biological weapon and the latter as a pesticide. B. anthracis and B. thuringiensis are readily distinguished from B. cereus by the presence of plasmid-borne specific toxins (B. anthracis and B. thuringiensis) and capsule (B. anthracis). But phylogenetic studies based on the analysis of chromosomal genes bring controversial results, and it is unclear whether B. cereus, B. anthracis and B. thuringiensis are varieties of the same species or different species. Here we report the sequencing and analysis of the type strain B. cereus ATCC 14579. The complete genome sequence of B. cereus ATCC 14579 together with the gapped genome of B. anthracis A2012 enables us to perform comparative analysis, and hence to identify the genes that are conserved between B. cereus and B. anthracis, and the genes that are unique for each species. We use the former to clarify the phylogeny of the cereus group, and the latter to determine plasmid-independent species-specific markers.
AB - Bacillus cereus is an opportunistic pathogen causing food poisoning manifested by diarrhoeal or emetic syndromes. It is closely related to the animal and human pathogen Bacillus anthracis and the insect pathogen Bacillus thuringiensis, the former being used as a biological weapon and the latter as a pesticide. B. anthracis and B. thuringiensis are readily distinguished from B. cereus by the presence of plasmid-borne specific toxins (B. anthracis and B. thuringiensis) and capsule (B. anthracis). But phylogenetic studies based on the analysis of chromosomal genes bring controversial results, and it is unclear whether B. cereus, B. anthracis and B. thuringiensis are varieties of the same species or different species. Here we report the sequencing and analysis of the type strain B. cereus ATCC 14579. The complete genome sequence of B. cereus ATCC 14579 together with the gapped genome of B. anthracis A2012 enables us to perform comparative analysis, and hence to identify the genes that are conserved between B. cereus and B. anthracis, and the genes that are unique for each species. We use the former to clarify the phylogeny of the cereus group, and the latter to determine plasmid-independent species-specific markers.
UR - http://www.scopus.com/inward/record.url?scp=0038752612&partnerID=8YFLogxK
U2 - 10.1038/nature01582
DO - 10.1038/nature01582
M3 - Article
C2 - 12721630
AN - SCOPUS:0038752612
VL - 423
SP - 87
EP - 91
JO - Nature
JF - Nature
SN - 0028-0836
IS - 6935
ER -
ID: 90040988