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Genetic Determinants of Rhythmic Movements Motor Pattern Generation in Drosophila Melanogaster. / Fedotov, S. A.; Bragina, Yu V.; Besedina, N. G.; Danilenkova, L. V.; Kamysheva, E. A.; Kamyshev, N. G.

в: Neuroscience and Behavioral Physiology, Том 44, № 9, 01.01.2014, стр. 995-1001.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Fedotov, SA, Bragina, YV, Besedina, NG, Danilenkova, LV, Kamysheva, EA & Kamyshev, NG 2014, 'Genetic Determinants of Rhythmic Movements Motor Pattern Generation in Drosophila Melanogaster', Neuroscience and Behavioral Physiology, Том. 44, № 9, стр. 995-1001. https://doi.org/10.1007/s11055-014-0015-2

APA

Fedotov, S. A., Bragina, Y. V., Besedina, N. G., Danilenkova, L. V., Kamysheva, E. A., & Kamyshev, N. G. (2014). Genetic Determinants of Rhythmic Movements Motor Pattern Generation in Drosophila Melanogaster. Neuroscience and Behavioral Physiology, 44(9), 995-1001. https://doi.org/10.1007/s11055-014-0015-2

Vancouver

Fedotov SA, Bragina YV, Besedina NG, Danilenkova LV, Kamysheva EA, Kamyshev NG. Genetic Determinants of Rhythmic Movements Motor Pattern Generation in Drosophila Melanogaster. Neuroscience and Behavioral Physiology. 2014 Янв. 1;44(9):995-1001. https://doi.org/10.1007/s11055-014-0015-2

Author

Fedotov, S. A. ; Bragina, Yu V. ; Besedina, N. G. ; Danilenkova, L. V. ; Kamysheva, E. A. ; Kamyshev, N. G. / Genetic Determinants of Rhythmic Movements Motor Pattern Generation in Drosophila Melanogaster. в: Neuroscience and Behavioral Physiology. 2014 ; Том 44, № 9. стр. 995-1001.

BibTeX

@article{109115cdd724405d95a0a866e040ef90,
title = "Genetic Determinants of Rhythmic Movements Motor Pattern Generation in Drosophila Melanogaster",
abstract = "Our previous studies of the molecular and cellular mechanisms underlying the generation of rhythmic movements motor patterns were based on use of a selection of candidate genes in which mutations cause impairments to the motor activity of Drosophila melanogaster. We report here testing of the locomotor behavior of Drosophila strains with decreases in the expression of 12 candidate genes in the nervous system. Target genes were suppressed by synthesizing interfering RNA using the GAL4/UAS system under the control of the elav, nrv2, appl, and tsh gene promoters (drivers). These experiments showed that RNA interference of virtually all the candidate genes was accompanied by changes in one or more locomotor parameters. The nature of the abnormalities occurring under the control the various drivers allowed us to identify those genes whose activity in nervous system cells is required for the normal functioning of the central motor pattern generator for locomotor acts.",
keywords = "central motor pattern generators, Drosophila, locomotion, RNA interference",
author = "Fedotov, {S. A.} and Bragina, {Yu V.} and Besedina, {N. G.} and Danilenkova, {L. V.} and Kamysheva, {E. A.} and Kamyshev, {N. G.}",
year = "2014",
month = jan,
day = "1",
doi = "10.1007/s11055-014-0015-2",
language = "English",
volume = "44",
pages = "995--1001",
journal = "Neuroscience and Behavioral Physiology",
issn = "0097-0549",
publisher = "Springer Nature",
number = "9",

}

RIS

TY - JOUR

T1 - Genetic Determinants of Rhythmic Movements Motor Pattern Generation in Drosophila Melanogaster

AU - Fedotov, S. A.

AU - Bragina, Yu V.

AU - Besedina, N. G.

AU - Danilenkova, L. V.

AU - Kamysheva, E. A.

AU - Kamyshev, N. G.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Our previous studies of the molecular and cellular mechanisms underlying the generation of rhythmic movements motor patterns were based on use of a selection of candidate genes in which mutations cause impairments to the motor activity of Drosophila melanogaster. We report here testing of the locomotor behavior of Drosophila strains with decreases in the expression of 12 candidate genes in the nervous system. Target genes were suppressed by synthesizing interfering RNA using the GAL4/UAS system under the control of the elav, nrv2, appl, and tsh gene promoters (drivers). These experiments showed that RNA interference of virtually all the candidate genes was accompanied by changes in one or more locomotor parameters. The nature of the abnormalities occurring under the control the various drivers allowed us to identify those genes whose activity in nervous system cells is required for the normal functioning of the central motor pattern generator for locomotor acts.

AB - Our previous studies of the molecular and cellular mechanisms underlying the generation of rhythmic movements motor patterns were based on use of a selection of candidate genes in which mutations cause impairments to the motor activity of Drosophila melanogaster. We report here testing of the locomotor behavior of Drosophila strains with decreases in the expression of 12 candidate genes in the nervous system. Target genes were suppressed by synthesizing interfering RNA using the GAL4/UAS system under the control of the elav, nrv2, appl, and tsh gene promoters (drivers). These experiments showed that RNA interference of virtually all the candidate genes was accompanied by changes in one or more locomotor parameters. The nature of the abnormalities occurring under the control the various drivers allowed us to identify those genes whose activity in nervous system cells is required for the normal functioning of the central motor pattern generator for locomotor acts.

KW - central motor pattern generators

KW - Drosophila

KW - locomotion

KW - RNA interference

UR - http://www.scopus.com/inward/record.url?scp=84921937650&partnerID=8YFLogxK

U2 - 10.1007/s11055-014-0015-2

DO - 10.1007/s11055-014-0015-2

M3 - Article

AN - SCOPUS:84921937650

VL - 44

SP - 995

EP - 1001

JO - Neuroscience and Behavioral Physiology

JF - Neuroscience and Behavioral Physiology

SN - 0097-0549

IS - 9

ER -

ID: 36036869