Результаты исследований: Научные публикации в периодических изданиях › статья
Functional link between ferroxidase activity of ceruloplasmin and protective effect of apo-lactoferrin: studying rats kept on a silver chloride diet. / Kostevich, V.A.; Sokolov, A.V.; Kozlov, S.O.; Vlasenko, A.Y.; Kolmakov, N.N.; Zakharova, E.T.; Vasilyev, V.B.
в: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, Том 29, № 4, 2016, стр. 691-704.Результаты исследований: Научные публикации в периодических изданиях › статья
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TY - JOUR
T1 - Functional link between ferroxidase activity of ceruloplasmin and protective effect of apo-lactoferrin: studying rats kept on a silver chloride diet
AU - Kostevich, V.A.
AU - Sokolov, A.V.
AU - Kozlov, S.O.
AU - Vlasenko, A.Y.
AU - Kolmakov, N.N.
AU - Zakharova, E.T.
AU - Vasilyev, V.B.
PY - 2016
Y1 - 2016
N2 - Strongly pronounced argyrosis caused by adding AgCl to the feed of laboratory rats efficiently mimics the deficiency of ceruloplasmin (CP) ferroxidase activity. Bringing the concentration of AgCl in the feedstuff of lactating rats to 250 mg % and keeping their progeny (Ag-rats) for 3 months on the same silver-containing feed provided the serum iron content 1.4 times lower than that in the control group. Besides, the ferroxidase activity of CP dropped to zero. In CP purified from sera of Ag-rats two copper ions were substituted with two silver ions. Using rat models of both post-hemorrhagic and hemolytic anemia we showed that the deficiency of CP ferroxidase activity in Ag-rats affects the iron content in serum, though does not prevent the recovery of hemoglobin level accompanied by exhaustion of iron caches in liver and spleen. When apo-lactoferrin (apo-LF) was administered to Ag-rats suffering from either post-hemorrhagic or hemolytic anemia, both hemoglobin and serum iron were restored more rapidly than in
AB - Strongly pronounced argyrosis caused by adding AgCl to the feed of laboratory rats efficiently mimics the deficiency of ceruloplasmin (CP) ferroxidase activity. Bringing the concentration of AgCl in the feedstuff of lactating rats to 250 mg % and keeping their progeny (Ag-rats) for 3 months on the same silver-containing feed provided the serum iron content 1.4 times lower than that in the control group. Besides, the ferroxidase activity of CP dropped to zero. In CP purified from sera of Ag-rats two copper ions were substituted with two silver ions. Using rat models of both post-hemorrhagic and hemolytic anemia we showed that the deficiency of CP ferroxidase activity in Ag-rats affects the iron content in serum, though does not prevent the recovery of hemoglobin level accompanied by exhaustion of iron caches in liver and spleen. When apo-lactoferrin (apo-LF) was administered to Ag-rats suffering from either post-hemorrhagic or hemolytic anemia, both hemoglobin and serum iron were restored more rapidly than in
KW - Ceruloplasmin
KW - Erythropoietin
KW - Ferroxidase
KW - Hemolytic anemia
KW - Hypoxia-inducible factor
KW - Iron metabolism
KW - Lactoferrin
KW - Post-hemorrhagic anemia
KW - Transferrin
U2 - 10.1007/s10534-016-9944-2
DO - 10.1007/s10534-016-9944-2
M3 - Article
VL - 29
SP - 691
EP - 704
JO - BioMetals
JF - BioMetals
SN - 0966-0844
IS - 4
ER -
ID: 7577667