The goal of the present study was to investigate functional interactions between brain structures during deliberate deception. On the basis of the results obtained and literature data, the following hypothesis has been formulated: the functional interaction between the brain areas responsible for executive control of the behavior localized in the prefrontal cortex (inferior frontal gyrus) and elements of the error detection system of the brain underlie deliberate deception. This hypothesis has been tested using psychophysiological interaction (PPI) analysis, which has revealed that deceptive actions (in comparison to truthful ones) are related to an increased functional connectivity between the left caudate nucleus and left inferior frontal gyrus. The experimental data support our hypothesis that the interaction of the brain systems responsible for executive control and error detection underpins the brain maintenance of execution of deceptive actions.