Результаты исследований: Научные публикации в периодических изданиях › статья
From past to future: suppressor mutations in yeast genes encoding translation termination factors. / Trubitsina, Nina; Zemlyanko, Olga; Moskalenko, Svetlana; Zhouravleva, Galina.
в: Biological Communications, Том 64, № 2, 2019, стр. 89-109.Результаты исследований: Научные публикации в периодических изданиях › статья
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TY - JOUR
T1 - From past to future: suppressor mutations in yeast genes encoding translation termination factors.
AU - Trubitsina, Nina
AU - Zemlyanko, Olga
AU - Moskalenko, Svetlana
AU - Zhouravleva, Galina
PY - 2019
Y1 - 2019
N2 - The study of the SUP45 and SUP35 genes of yeast Saccharomyces cerevisiae in the laboratory of Physiological Genetics of St. Petersburg State University began in 1964 when the first omnipotent nonsense suppressor mutations were obtained. During the following 55 years, a lot of information about these genes has been gained through the research efforts of various laboratories. Now we know that SUP45 and SUP35 encode translation termination factors eRF1 and eRF3, respectively. Both genes are essential, and sup45 and sup35 mutations lead not only to impaired translation but also to multiple pleiotropic effects. The aim of this review is to summarize known data about suppressor mutations in SUP45 or SUP35 genes.
AB - The study of the SUP45 and SUP35 genes of yeast Saccharomyces cerevisiae in the laboratory of Physiological Genetics of St. Petersburg State University began in 1964 when the first omnipotent nonsense suppressor mutations were obtained. During the following 55 years, a lot of information about these genes has been gained through the research efforts of various laboratories. Now we know that SUP45 and SUP35 encode translation termination factors eRF1 and eRF3, respectively. Both genes are essential, and sup45 and sup35 mutations lead not only to impaired translation but also to multiple pleiotropic effects. The aim of this review is to summarize known data about suppressor mutations in SUP45 or SUP35 genes.
KW - [PSI+] prion
KW - eRF1
KW - eRF3
KW - Missense mutations
KW - nonsense mutations
KW - S. cerevisiae
KW - Sup35
KW - Sup45
KW - suppression
KW - Translation termination
KW - [PSI+] prion
KW - eRF1
KW - eRF3
KW - Missense mutations
KW - nonsense mutations
KW - S. cerevisiae
KW - Sup35
KW - Sup45
KW - suppression
KW - Translation termination
M3 - Article
VL - 64
SP - 89
EP - 109
JO - Biological Communications
JF - Biological Communications
SN - 2542-2154
IS - 2
ER -
ID: 78489615