Reactions of layered perovskite-like oxides K₂La₂Ti₃O₁₀, NaLaTiO₄ and corresponding protonated oxides H₂La₂Ti₃O₁₀, HLaTiO₄ with vanadyl sulfate aqueous solution have been studied. It was revealed that the exchange reaction of interlayer alkali cations in K₂La₂Ti₃O₁₀ and NaLaTiO₄ by with vanadyl cations, which was reported in the literature previously, does not proceed. The formation of the corresponding protonated forms and vanadium-containing particles is found to occur instead. In the case of protonated forms H₂La₂Ti₃O₁₀, HLaTiO₄ vanadium-containing nanostructures are formed on the surface.