Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Formation of RNA spatial structures. / Leonova, E. I.; Baranov, M. V.; Galzitskaya, O. V.
в: Molecular Biology, Том 46, № 1, 01.02.2012, стр. 34-46.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
}
TY - JOUR
T1 - Formation of RNA spatial structures
AU - Leonova, E. I.
AU - Baranov, M. V.
AU - Galzitskaya, O. V.
PY - 2012/2/1
Y1 - 2012/2/1
N2 - The review considers different experimental and theoretical approaches to the investigation of RNA folding and identification of nucleotides that critically affect the folding of molecules, such as tRNA, and several classes of ribozymes. For instance, it has been shown that nucleotides of the D- and T-loop regions are the last to be involved in the tRNA structure, or, rather, they are not included in the tRNA folding nucleus. A specially developed SHAPE method was used to show that the long-recognized hierarchical folding model does not hold true for tRNA folding. In the second part of the review, algorithms and programs used for the prediction of RNA secondary structures, as well as for modeling RNA folding, are considered.
AB - The review considers different experimental and theoretical approaches to the investigation of RNA folding and identification of nucleotides that critically affect the folding of molecules, such as tRNA, and several classes of ribozymes. For instance, it has been shown that nucleotides of the D- and T-loop regions are the last to be involved in the tRNA structure, or, rather, they are not included in the tRNA folding nucleus. A specially developed SHAPE method was used to show that the long-recognized hierarchical folding model does not hold true for tRNA folding. In the second part of the review, algorithms and programs used for the prediction of RNA secondary structures, as well as for modeling RNA folding, are considered.
KW - base stacking
KW - folding nucleus
KW - H-bonds
KW - hydrophobic interactions
KW - nonhierarchical model of folding
KW - RNA folding
UR - http://www.scopus.com/inward/record.url?scp=84857201910&partnerID=8YFLogxK
U2 - 10.1134/S0026893312010104
DO - 10.1134/S0026893312010104
M3 - Review article
C2 - 22642100
AN - SCOPUS:84857201910
VL - 46
SP - 34
EP - 46
JO - Molecular Biology
JF - Molecular Biology
SN - 0026-8933
IS - 1
ER -
ID: 45420063