TY - JOUR

T1 - Formation and chromatographic detection of organic compound hydrates

AU - Зенкевич, Игорь Георгиевич

AU - Никитина, Дарья Александровна

AU - Деруиш, Абденнур

N1 - Zenkevich I.G., Nikitina D.A., Derouich A. // J. Analyt. Chem. (Rus.). 2021. V. 76. № 4. P. 493-502.

PY - 2021/4

Y1 - 2021/4

N2 - Abstract: The formation of hydrates of inorganic compounds is well known and is widely discussed in the contemporary literature. The reasons for the insufficiently detailed characterization of numerous well-known hydrates of organic compounds are analyzed, the main of which is their instability. The CAS numbers assigned to many of these hydrates confirm interest in these hydrates. We found that the reversible formation of the hydrates of various organic compounds can be a reason for anomalous dependences of their retention parameters (t R) on the concentration of an organic eluent modifier (c) in reversed-phase high-performance liquid chromatography. The recurrent approximation of the retention parameters t R(c + Δc) = at R(c) + b (*), where Δc = const is a constant step of c, is the most effective way to detect these anomalies. Deviations of dependences like (*) from linearity are observed with compounds in which variations in c and, consequently, in the water content of the eluent (1 – c) affect the equilibrium of the reaction Х + nH2O X nH2O.

AB - Abstract: The formation of hydrates of inorganic compounds is well known and is widely discussed in the contemporary literature. The reasons for the insufficiently detailed characterization of numerous well-known hydrates of organic compounds are analyzed, the main of which is their instability. The CAS numbers assigned to many of these hydrates confirm interest in these hydrates. We found that the reversible formation of the hydrates of various organic compounds can be a reason for anomalous dependences of their retention parameters (t R) on the concentration of an organic eluent modifier (c) in reversed-phase high-performance liquid chromatography. The recurrent approximation of the retention parameters t R(c + Δc) = at R(c) + b (*), where Δc = const is a constant step of c, is the most effective way to detect these anomalies. Deviations of dependences like (*) from linearity are observed with compounds in which variations in c and, consequently, in the water content of the eluent (1 – c) affect the equilibrium of the reaction Х + nH2O X nH2O.

KW - в тексте публикации

KW - anomalies of retention parameters

KW - high-performance liquid chromatography

KW - hydrates

KW - organic compounds

KW - recurrent approximation

UR - http://www.scopus.com/inward/record.url?scp=85104464568&partnerID=8YFLogxK

U2 - 10.1134/S1061934821040146

DO - 10.1134/S1061934821040146

M3 - Article

VL - 76

SP - 493

EP - 502

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

SN - 1061-9348

IS - 4

ER -