TY - JOUR

T1 - Fetal growth regulation via insulin-like growth factor axis in normal and diabetic pregnancy

AU - Alekseenkova, Elena N.

AU - Selkov, Sergey A.

AU - Kapustin, Roman V.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Objectives: Diabetes mellitus (DM) in pregnancy and gestational diabetes remain a considerable cause of pregnancy complications, and fetal macrosomia is among them. Insulin, insulin-like growth factors (IGFs), and components of their signal-transduction axes belong to the predominant growth regulators and are implicated in glucose homeostasis. This study aimed to evaluate the available evidence on the association between the IGF axis and fetal anthropometric parameters in human diabetic pregnancy. Methods: PubMed, Medline, Web of Science, and CNKI databases (1981-2021) were searched. Results: Maternal and cord serum IGF-I levels are suggested to be positively associated with weight and length of neonates born to mothers with type 1 DM. The results concerning IGF-II and IGFBPs in type 1 DM or any of the IGF axis components in type 2 DM remain controversial. The alterations of maternal serum IGFs concentrations throughout diabetic and non-diabetic pregnancy do not appear to be the same. Maternal 1st trimester IGF-I level is positively associated with fetal birth weight in DM. Conclusions: Research on the IGF axis should take gestational age of sampling, presence of DM, and insulin administration into account. Maternal 1st trimester IGF-I level might become a predictor for macrosomia development in diabetic pregnancy.

AB - Objectives: Diabetes mellitus (DM) in pregnancy and gestational diabetes remain a considerable cause of pregnancy complications, and fetal macrosomia is among them. Insulin, insulin-like growth factors (IGFs), and components of their signal-transduction axes belong to the predominant growth regulators and are implicated in glucose homeostasis. This study aimed to evaluate the available evidence on the association between the IGF axis and fetal anthropometric parameters in human diabetic pregnancy. Methods: PubMed, Medline, Web of Science, and CNKI databases (1981-2021) were searched. Results: Maternal and cord serum IGF-I levels are suggested to be positively associated with weight and length of neonates born to mothers with type 1 DM. The results concerning IGF-II and IGFBPs in type 1 DM or any of the IGF axis components in type 2 DM remain controversial. The alterations of maternal serum IGFs concentrations throughout diabetic and non-diabetic pregnancy do not appear to be the same. Maternal 1st trimester IGF-I level is positively associated with fetal birth weight in DM. Conclusions: Research on the IGF axis should take gestational age of sampling, presence of DM, and insulin administration into account. Maternal 1st trimester IGF-I level might become a predictor for macrosomia development in diabetic pregnancy.

KW - birth weight

KW - diabetes mellitus

KW - fetal growth

KW - IGF

KW - insulin-like growth factor

KW - macrosomia

UR - http://www.scopus.com/inward/record.url?scp=85128560803&partnerID=8YFLogxK

U2 - 10.1515/jpm-2021-0510

DO - 10.1515/jpm-2021-0510

M3 - Article

C2 - 35363447

AN - SCOPUS:85128560803

VL - 50

SP - 947

EP - 960

JO - Journal of Perinatal Medicine

JF - Journal of Perinatal Medicine

SN - 0300-5577

IS - 7

ER -