Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Hitherto undescribed 3-unsubstituted tetrahydroisoquinolonic acids (isolated as their respective methyl esters) were accessed for the first time by the uncatalyzed, thermally promoted Castagnoli-Cushman reaction (CCR) of homophthalic anhydride (HPA) and a series of 1,3,5-triazinanes. The moderate yields observed in some cases are most likely associated with a persistent impurity also formed in these reactions. The new scaffold is expected to find novel medicinal utility (compared to the traditional CCR adducts) because it lacks a substituent at the 3-position.
Язык оригинала | английский |
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Номер статьи | ss-2017-t0751-op |
Страницы (с-по) | 2001-2008 |
Число страниц | 8 |
Журнал | Synthesis (Germany) |
Том | 50 |
Номер выпуска | 10 |
DOI | |
Состояние | Опубликовано - 17 мая 2018 |
ID: 34632089