TY - JOUR

T1 - Extracellular Vesicles as Biomarkers of Pregnancy Complications

AU - Popova, A.K.

AU - Vashukova, E.S.

AU - Illarionov, R.A.

AU - Maltseva, A.R.

AU - Pachuliia, O.V.

AU - Postnikova, T.B.

AU - Glotov, A.S.

N1 - Export Date: 01 November 2025; Cited By: 10; Correspondence Address: A.S. Glotov; Department of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, Russian Federation; email: anglotov@mail.ru

PY - 2024

Y1 - 2024

N2 - Extracellular vesicles (EVs) are double-membrane vesicles that facilitate intercellular communication and play a pivotal role in both physiological and pathological processes. A substantial body of evidence suggests that EVs play a role in the pathogenesis of various pregnancy complications. Because EVs can be detected in the peripheral blood, they are potential biomarkers for the early diagnosis of pregnancy complications and foetal developmental disorders. The majority of studies have demonstrated a correlation between alterations in the concentration of EVs and changes in their contents and the occurrence of pregnancy complications. Despite the current limitations in establishing a clear link between these findings and the pathogenesis of the disease, as well as the lack of sufficient evidence to support their use in clinical practice, it is noteworthy to highlight the potential role of specific miRNAs carried by EVs in the development of pregnancy complications. These include miR-210 and miR-136-5p for pre-eclampsia and gestational diabetes mellitus, miR-155, miR-26b-5p, miR-181a-5p, miR-495 and miR-374c for pre-eclampsia and preterm birth. The following miRNAs have been identified as potential biomarkers for preterm birth and gestational diabetes mellitus: miR-197-3p and miR-520h, miR-1323, miR-342-3p, miR-132-3p, miR-182-3p, miR-517-3p, miR-222-3p, miR-16-5p and miR-126-3p. Additionally, miR-127-3p has been linked to foetal growth restriction and preterm birth. Nevertheless, it would be premature to propose that EVs can be employed as biomarkers for pregnancy complications. Further research and the accumulation of results obtained using the methods proposed in the MISEV2023 guidelines will enable a definitive conclusion to be reached. © 2024 Elsevier B.V., All rights reserved.

AB - Extracellular vesicles (EVs) are double-membrane vesicles that facilitate intercellular communication and play a pivotal role in both physiological and pathological processes. A substantial body of evidence suggests that EVs play a role in the pathogenesis of various pregnancy complications. Because EVs can be detected in the peripheral blood, they are potential biomarkers for the early diagnosis of pregnancy complications and foetal developmental disorders. The majority of studies have demonstrated a correlation between alterations in the concentration of EVs and changes in their contents and the occurrence of pregnancy complications. Despite the current limitations in establishing a clear link between these findings and the pathogenesis of the disease, as well as the lack of sufficient evidence to support their use in clinical practice, it is noteworthy to highlight the potential role of specific miRNAs carried by EVs in the development of pregnancy complications. These include miR-210 and miR-136-5p for pre-eclampsia and gestational diabetes mellitus, miR-155, miR-26b-5p, miR-181a-5p, miR-495 and miR-374c for pre-eclampsia and preterm birth. The following miRNAs have been identified as potential biomarkers for preterm birth and gestational diabetes mellitus: miR-197-3p and miR-520h, miR-1323, miR-342-3p, miR-132-3p, miR-182-3p, miR-517-3p, miR-222-3p, miR-16-5p and miR-126-3p. Additionally, miR-127-3p has been linked to foetal growth restriction and preterm birth. Nevertheless, it would be premature to propose that EVs can be employed as biomarkers for pregnancy complications. Further research and the accumulation of results obtained using the methods proposed in the MISEV2023 guidelines will enable a definitive conclusion to be reached. © 2024 Elsevier B.V., All rights reserved.

KW - biomarkers

KW - extracellular vesicles

KW - pregnancy

KW - pregnancy complications

KW - biological marker

KW - microRNA

KW - microRNA 126

KW - microRNA 132

KW - microRNA 155

KW - microRNA 16

KW - microRNA 182

KW - microRNA 210

KW - microRNA 222

KW - clinical practice

KW - cohort analysis

KW - controlled study

KW - diagnosis

KW - early diagnosis

KW - etiology

KW - exosome

KW - female

KW - fetus development

KW - gestational diabetes

KW - human

KW - intrauterine growth retardation

KW - membrane vesicle

KW - pathogenesis

KW - preeclampsia

KW - pregnancy complication

KW - review

KW - genetics

KW - metabolism

KW - Biomarkers

KW - Diabetes, Gestational

KW - Extracellular Vesicles

KW - Female

KW - Humans

KW - MicroRNAs

KW - Pre-Eclampsia

KW - Pregnancy

KW - Pregnancy Complications

U2 - 10.3390/ijms252211944

DO - 10.3390/ijms252211944

M3 - статья

VL - 25

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 22

ER -