TY - JOUR

T1 - Expression pattern of arenicins - the antimicrobial peptides of polychaete Arenicola marina

AU - Maltseva, A.L.

AU - Kotenko, O.N.

AU - Kokryakov, V.N.

AU - Starunov, V.V.

AU - Krasnodembskaya, A.D.

PY - 2014

Y1 - 2014

N2 - Immune responses of invertebrate animals are mediated through innate mechanisms, among which production of antimicrobial peptides plays an important role. Although evolutionary Polychaetes represent an interesting group closely related to presumable common ancestor of other coelomates, their immune mechanisms still remain scarcely investigated. Previously our group has identified arenicins - new antimicrobial peptides of the lugworm Arenicola marina, since then these peptides were thoroughly characterized in terms of their structure and inhibitory potential. In the present study we addressed the question of the physiological functions of arenicins in the lugworm body. Using molecular and immunocytochemical methods we demonstrated that arencins are expressed in the wide range of the lugworm tissues - coelomocytes, body wall, extravasal tissue and the gut. The expression of arenicins is constitutive and does not depend on stimulation of various infectious stimuli. Most intensively arenicins are produced by matu

AB - Immune responses of invertebrate animals are mediated through innate mechanisms, among which production of antimicrobial peptides plays an important role. Although evolutionary Polychaetes represent an interesting group closely related to presumable common ancestor of other coelomates, their immune mechanisms still remain scarcely investigated. Previously our group has identified arenicins - new antimicrobial peptides of the lugworm Arenicola marina, since then these peptides were thoroughly characterized in terms of their structure and inhibitory potential. In the present study we addressed the question of the physiological functions of arenicins in the lugworm body. Using molecular and immunocytochemical methods we demonstrated that arencins are expressed in the wide range of the lugworm tissues - coelomocytes, body wall, extravasal tissue and the gut. The expression of arenicins is constitutive and does not depend on stimulation of various infectious stimuli. Most intensively arenicins are produced by matu

KW - antimicrobial peptides

KW - invertebrate immunity

KW - coelomocytes

KW - Arenicola marina

KW - annelids

U2 - 10.3389/fphys.2014.00497

DO - 10.3389/fphys.2014.00497

M3 - Article

VL - 5

SP - 497 (1-11)

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

ER -