TY - JOUR

T1 - Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders

AU - Vengerovich, N G

AU - Drachkova, I M

AU - Yudin, M A

AU - Bykov, V N

AU - Sarana, A M

PY - 2018/6

Y1 - 2018/6

N2 - We studied the dynamics of respiratory function in rats during intratracheal poisoning with diisopropyl fluorophosphate and pentylenetetrazole in doses corresponding to the LD50 in humans. The maximum of external respiration impairment was recorded in 30 min after poisoning. Administration of diazepam and atropine both separately and in combination during the development of the first signs of poisoning did not significantly affect the respiration parameters, but reduced the incidence of seizures and contributed to a decrease in the rate of animal death. Intratracheal administration of cholinolytic, β2-adrenomimetic, or glutamate receptors antagonist promoted correction of the respiratory function. It was found that the maximum therapeutic effect in case of diisopropyl fluorophosphates poisoning was achieved after intratracheal administration of ipratropium bromide (0.086 mg/kg), salbutamol (0.086 mg/kg), and MK-801 (0.1 mg/kg), while in case of pentylenetetrazole poisoning, intratracheal administration of ipratropium bromide (0.086 mg/kg) was most effective.

AB - We studied the dynamics of respiratory function in rats during intratracheal poisoning with diisopropyl fluorophosphate and pentylenetetrazole in doses corresponding to the LD50 in humans. The maximum of external respiration impairment was recorded in 30 min after poisoning. Administration of diazepam and atropine both separately and in combination during the development of the first signs of poisoning did not significantly affect the respiration parameters, but reduced the incidence of seizures and contributed to a decrease in the rate of animal death. Intratracheal administration of cholinolytic, β2-adrenomimetic, or glutamate receptors antagonist promoted correction of the respiratory function. It was found that the maximum therapeutic effect in case of diisopropyl fluorophosphates poisoning was achieved after intratracheal administration of ipratropium bromide (0.086 mg/kg), salbutamol (0.086 mg/kg), and MK-801 (0.1 mg/kg), while in case of pentylenetetrazole poisoning, intratracheal administration of ipratropium bromide (0.086 mg/kg) was most effective.

KW - Administration, Inhalation

KW - Albuterol/administration & dosage

KW - Animals

KW - Atropine/administration & dosage

KW - Bronchodilator Agents/administration & dosage

KW - Convulsants/poisoning

KW - Diazepam/administration & dosage

KW - Epilepsy/complications

KW - Ipratropium/administration & dosage

KW - Isoflurophate/poisoning

KW - Male

KW - Pentylenetetrazole/poisoning

KW - Rats

KW - Respiration Disorders/chemically induced

KW - Respiratory Mechanics/drug effects

KW - Seizures/complications

U2 - 10.1007/s10517-018-4135-5

DO - 10.1007/s10517-018-4135-5

M3 - Article

C2 - 29922996

VL - 165

SP - 225

EP - 229

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 2

ER -