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Experimental Models of Anxiety for Drug Discovery and Brain Research. / Hart, P. C.; Bergner, C. L.; Smolinsky, A. N.; Dufour, B. D.; Egan, R. J.; LaPorte, J. L.; Kalueff, A. V.

в: Methods in Molecular Biology, № 1438, 2016, стр. 271-291.

Результаты исследований: Научные публикации в периодических изданиях › Обзор литературы

Harvard

Hart, PC, Bergner, CL, Smolinsky, AN, Dufour, BD, Egan, RJ, LaPorte, JL & Kalueff, AV 2016, 'Experimental Models of Anxiety for Drug Discovery and Brain Research.', Methods in Molecular Biology, № 1438, стр. 271-291. https://doi.org/10.1007/978-1-4939-3661-8_16

APA

Hart, P. C., Bergner, C. L., Smolinsky, A. N., Dufour, B. D., Egan, R. J., LaPorte, J. L., & Kalueff, A. V. (2016). Experimental Models of Anxiety for Drug Discovery and Brain Research. Methods in Molecular Biology, (1438), 271-291. https://doi.org/10.1007/978-1-4939-3661-8_16

Vancouver

Hart PC, Bergner CL, Smolinsky AN, Dufour BD, Egan RJ, LaPorte JL и пр. Experimental Models of Anxiety for Drug Discovery and Brain Research. Methods in Molecular Biology. 2016;(1438):271-291. https://doi.org/10.1007/978-1-4939-3661-8_16

Author

Hart, P. C. ; Bergner, C. L. ; Smolinsky, A. N. ; Dufour, B. D. ; Egan, R. J. ; LaPorte, J. L. ; Kalueff, A. V. / Experimental Models of Anxiety for Drug Discovery and Brain Research. в: Methods in Molecular Biology. 2016 ; № 1438. стр. 271-291.

BibTeX

@article{e0281b7103ac4a558d1c3cf9fef4adb8,
title = "Experimental Models of Anxiety for Drug Discovery and Brain Research.",
abstract = "Animal models have been vital to recent advances in experimental neuroscience, including the modeling of common human brain disorders such as anxiety, depression, and schizophrenia. As mice express robust anxiety-like behaviors when exposed to stressors (e.g., novelty, bright light, or social confrontation), these phenotypes have clear utility in testing the effects of psychotropic drugs. Of specific interest is the extent to which mouse models can be used for the screening of new anxiolytic drugs and verification of their possible applications in humans. To address this problem, the present chapter will review different experimental models of mouse anxiety and discuss their utility for testing anxiolytic and anxiogenic drugs. Detailed protocols will be provided for these paradigms, and possible confounds will be addressed accordingly.",
keywords = "Anxiety, Anxiogenic drugs, Anxiolytic drugs, Biological psychiatry, Experimental animal models, Exploration",
author = "Hart, {P. C.} and Bergner, {C. L.} and Smolinsky, {A. N.} and Dufour, {B. D.} and Egan, {R. J.} and LaPorte, {J. L.} and Kalueff, {A. V.}",
year = "2016",
doi = "10.1007/978-1-4939-3661-8_16",
language = "English",
pages = "271--291",
journal = "Methods in Molecular Biology",
issn = "1064-3745",
publisher = "Humana Press",
number = "1438",

}

RIS

TY - JOUR

T1 - Experimental Models of Anxiety for Drug Discovery and Brain Research.

AU - Hart, P. C.

AU - Bergner, C. L.

AU - Smolinsky, A. N.

AU - Dufour, B. D.

AU - Egan, R. J.

AU - LaPorte, J. L.

AU - Kalueff, A. V.

PY - 2016

Y1 - 2016

N2 - Animal models have been vital to recent advances in experimental neuroscience, including the modeling of common human brain disorders such as anxiety, depression, and schizophrenia. As mice express robust anxiety-like behaviors when exposed to stressors (e.g., novelty, bright light, or social confrontation), these phenotypes have clear utility in testing the effects of psychotropic drugs. Of specific interest is the extent to which mouse models can be used for the screening of new anxiolytic drugs and verification of their possible applications in humans. To address this problem, the present chapter will review different experimental models of mouse anxiety and discuss their utility for testing anxiolytic and anxiogenic drugs. Detailed protocols will be provided for these paradigms, and possible confounds will be addressed accordingly.

AB - Animal models have been vital to recent advances in experimental neuroscience, including the modeling of common human brain disorders such as anxiety, depression, and schizophrenia. As mice express robust anxiety-like behaviors when exposed to stressors (e.g., novelty, bright light, or social confrontation), these phenotypes have clear utility in testing the effects of psychotropic drugs. Of specific interest is the extent to which mouse models can be used for the screening of new anxiolytic drugs and verification of their possible applications in humans. To address this problem, the present chapter will review different experimental models of mouse anxiety and discuss their utility for testing anxiolytic and anxiogenic drugs. Detailed protocols will be provided for these paradigms, and possible confounds will be addressed accordingly.

KW - Anxiety

KW - Anxiogenic drugs

KW - Anxiolytic drugs

KW - Biological psychiatry

KW - Experimental animal models

KW - Exploration

U2 - 10.1007/978-1-4939-3661-8_16

DO - 10.1007/978-1-4939-3661-8_16

M3 - Literature review

SP - 271

EP - 291

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

SN - 1064-3745

IS - 1438

ER -

ID: 7590154