Standard

Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells. / Abdurasulova, I. N.; Matsulevich, A. V.; Tarasova, E. A.; Kudryavtsev, I. V.; Serebrjakova, M. K.; Ermolenko, E. I.; Bisaga, G. N.; Klimenko, V. M.; Suvorov, A. N.

в: Beneficial microbes, Том 7, № 5, 2016, стр. 719-729.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

APA

Vancouver

Author

Abdurasulova, I. N. ; Matsulevich, A. V. ; Tarasova, E. A. ; Kudryavtsev, I. V. ; Serebrjakova, M. K. ; Ermolenko, E. I. ; Bisaga, G. N. ; Klimenko, V. M. ; Suvorov, A. N. / Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells. в: Beneficial microbes. 2016 ; Том 7, № 5. стр. 719-729.

BibTeX

@article{028e390a80c240009f65ab6595e48264,
title = "Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells",
abstract = "The effect of probiotic Enterococcus faecium strain L-3 was studied in rats with experimental allergic encephalomyelitis (EAE). Glatiramer acetate (GA) was used as control drug. E. faecium strain L-3 and GA both were able to reduce the severity of EAE in a similar fashion. Both approaches increased the proportion of EAE resistant rats and rats with mild disease, prolonged the inductive phase of EAE and reduced the disease duration. Study of the phenotypes of immune cells in blood revealed the differences in immunoregulatory pathways that mediate the protective action of probiotic or GA treatment of EAE. The presence of pronounced protective and immunomodulating effects of the probiotic E. faecium strain L-3 opens an opportunity of its application for the treatment of multiple sclerosis.",
keywords = "Enterococcus faecium, Experimental allergic encephalomyelitis, Immunomodulation, Intestinal microbiota, Multiple sclerosis, Neuroprotection, Probiotics",
author = "Abdurasulova, {I. N.} and Matsulevich, {A. V.} and Tarasova, {E. A.} and Kudryavtsev, {I. V.} and Serebrjakova, {M. K.} and Ermolenko, {E. I.} and Bisaga, {G. N.} and Klimenko, {V. M.} and Suvorov, {A. N.}",
note = "Publisher Copyright: {\textcopyright} 2016 Wageningen Academic Publishers. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2016",
doi = "10.3920/BM2016.0018",
language = "English",
volume = "7",
pages = "719--729",
journal = "Beneficial microbes",
issn = "1876-2883",
publisher = "Wageningen Academic Publishers",
number = "5",

}

RIS

TY - JOUR

T1 - Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells

AU - Abdurasulova, I. N.

AU - Matsulevich, A. V.

AU - Tarasova, E. A.

AU - Kudryavtsev, I. V.

AU - Serebrjakova, M. K.

AU - Ermolenko, E. I.

AU - Bisaga, G. N.

AU - Klimenko, V. M.

AU - Suvorov, A. N.

N1 - Publisher Copyright: © 2016 Wageningen Academic Publishers. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2016

Y1 - 2016

N2 - The effect of probiotic Enterococcus faecium strain L-3 was studied in rats with experimental allergic encephalomyelitis (EAE). Glatiramer acetate (GA) was used as control drug. E. faecium strain L-3 and GA both were able to reduce the severity of EAE in a similar fashion. Both approaches increased the proportion of EAE resistant rats and rats with mild disease, prolonged the inductive phase of EAE and reduced the disease duration. Study of the phenotypes of immune cells in blood revealed the differences in immunoregulatory pathways that mediate the protective action of probiotic or GA treatment of EAE. The presence of pronounced protective and immunomodulating effects of the probiotic E. faecium strain L-3 opens an opportunity of its application for the treatment of multiple sclerosis.

AB - The effect of probiotic Enterococcus faecium strain L-3 was studied in rats with experimental allergic encephalomyelitis (EAE). Glatiramer acetate (GA) was used as control drug. E. faecium strain L-3 and GA both were able to reduce the severity of EAE in a similar fashion. Both approaches increased the proportion of EAE resistant rats and rats with mild disease, prolonged the inductive phase of EAE and reduced the disease duration. Study of the phenotypes of immune cells in blood revealed the differences in immunoregulatory pathways that mediate the protective action of probiotic or GA treatment of EAE. The presence of pronounced protective and immunomodulating effects of the probiotic E. faecium strain L-3 opens an opportunity of its application for the treatment of multiple sclerosis.

KW - Enterococcus faecium

KW - Experimental allergic encephalomyelitis

KW - Immunomodulation

KW - Intestinal microbiota

KW - Multiple sclerosis

KW - Neuroprotection

KW - Probiotics

UR - http://www.scopus.com/inward/record.url?scp=85006789746&partnerID=8YFLogxK

U2 - 10.3920/BM2016.0018

DO - 10.3920/BM2016.0018

M3 - Article

C2 - 27633171

AN - SCOPUS:85006789746

VL - 7

SP - 719

EP - 729

JO - Beneficial microbes

JF - Beneficial microbes

SN - 1876-2883

IS - 5

ER -

ID: 27947463