Results of endoscopic interventions on 72 patients with portal hypertension of different etiology are presented. In patients with acute bleedings the frequency of primary hemostasis was 94%. In 2 patients with hemorrhages from the cardial veins of the stomach the endoscopic interventions proved to be ineffective. Prophylactic treatment gave 20% recurrent bleedings during a year. Survival of the patients during 6 months was 88.5% and considerably depended on the functional group according to Child. The endoscopic interventions (sclerotherapy, ligation) should be considered effective methods to arrest bleeding and to prevent bleedings of portal genesis.