TY - JOUR

T1 - Ellipsoid Body and Medulla Defects and Locomotion Disturbances in sbr (small bristles) Mutants of Drosophila melanogaster

AU - Yakimova, A. O.

AU - Golubkova, E. V.

AU - Mamon, L. A.

AU - Sarantseva, S. V.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - The sbr gene is an ortholog of evolutionarily conservative nxf1 (nuclear export factor) genes that control nuclear-cytoplasmic transport of mRNA in various eukaryotic organisms. Mutations of sbr exhibit a broad range of pleiotropic effects, which are characteristic of “housekeeping” genes. Certain allele-specific manifestations of the sbr gene in neurogenesis and behavior facilitate a deeper understanding of not only universal but also highly specialized functions of this gene. Among such characteristic features of adult males with an sbr12 mutation are reduced locomotor activity as revealed in the negative geotaxis test and significant morphological disruptions of the ellipsoid body and the medulla, both of which are important for locomotion. The character of defects in the ellipsoid body and the medulla suggests that the SBR protein is essential for the normal formation and functioning of these nerve centers, and that the protein carries not only universal but also specialized functions.

AB - The sbr gene is an ortholog of evolutionarily conservative nxf1 (nuclear export factor) genes that control nuclear-cytoplasmic transport of mRNA in various eukaryotic organisms. Mutations of sbr exhibit a broad range of pleiotropic effects, which are characteristic of “housekeeping” genes. Certain allele-specific manifestations of the sbr gene in neurogenesis and behavior facilitate a deeper understanding of not only universal but also highly specialized functions of this gene. Among such characteristic features of adult males with an sbr12 mutation are reduced locomotor activity as revealed in the negative geotaxis test and significant morphological disruptions of the ellipsoid body and the medulla, both of which are important for locomotion. The character of defects in the ellipsoid body and the medulla suggests that the SBR protein is essential for the normal formation and functioning of these nerve centers, and that the protein carries not only universal but also specialized functions.

KW - ellipsoid body

KW - locomotor behavior

KW - neurogenesis

KW - nxf1 (nuclear export factor)

KW - optic lobe

KW - sbr (small bristles)

UR - http://www.scopus.com/inward/record.url?scp=85049315581&partnerID=8YFLogxK

UR - https://elibrary.ru/item.asp?id=35746613

U2 - 10.1134/S1022795418060145

DO - 10.1134/S1022795418060145

M3 - Article

AN - SCOPUS:85049315581

VL - 54

SP - 609

EP - 617

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 6

ER -