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Efficient synthesis, structure and anti-influenza virus activity of fluorinated pyrido[4,3-b][1,4]thiazine 1,1-dioxide derivatives. / Politanskaya, Larisa; Khasanov, Bulat; Bagryanskaya, Irina; Niukalova, Maria; Aksakov, Sergey; Balashova, Irina; Zarubaev, Vladimir V.

в: Journal of Fluorine Chemistry, Том 283-284, 110430, 01.04.2025.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Politanskaya, L, Khasanov, B, Bagryanskaya, I, Niukalova, M, Aksakov, S, Balashova, I & Zarubaev, VV 2025, 'Efficient synthesis, structure and anti-influenza virus activity of fluorinated pyrido[4,3-b][1,4]thiazine 1,1-dioxide derivatives.', Journal of Fluorine Chemistry, Том. 283-284, 110430. https://doi.org/10.1016/j.jfluchem.2025.110430

APA

Politanskaya, L., Khasanov, B., Bagryanskaya, I., Niukalova, M., Aksakov, S., Balashova, I., & Zarubaev, V. V. (2025). Efficient synthesis, structure and anti-influenza virus activity of fluorinated pyrido[4,3-b][1,4]thiazine 1,1-dioxide derivatives. Journal of Fluorine Chemistry, 283-284, [110430]. https://doi.org/10.1016/j.jfluchem.2025.110430

Vancouver

Politanskaya L, Khasanov B, Bagryanskaya I, Niukalova M, Aksakov S, Balashova I и пр. Efficient synthesis, structure and anti-influenza virus activity of fluorinated pyrido[4,3-b][1,4]thiazine 1,1-dioxide derivatives. Journal of Fluorine Chemistry. 2025 Апр. 1;283-284. 110430. https://doi.org/10.1016/j.jfluchem.2025.110430

Author

Politanskaya, Larisa ; Khasanov, Bulat ; Bagryanskaya, Irina ; Niukalova, Maria ; Aksakov, Sergey ; Balashova, Irina ; Zarubaev, Vladimir V. / Efficient synthesis, structure and anti-influenza virus activity of fluorinated pyrido[4,3-b][1,4]thiazine 1,1-dioxide derivatives. в: Journal of Fluorine Chemistry. 2025 ; Том 283-284.

BibTeX

@article{191fc0fb31b448d9b8e5312ad270b49e,
title = "Efficient synthesis, structure and anti-influenza virus activity of fluorinated pyrido[4,3-b][1,4]thiazine 1,1-dioxide derivatives.",
abstract = "A series of fluorinated bicyclic fused compounds, containing fragments of pyridine and 3,4-dihydro-2H-1,4-thiazine 1,1-dioxide were synthesized via one-pot substitution of halogen atoms by N-nucleophiles in polyfluorinated precursor. Formation of the heterocyclic moiety was proceed as a two-stage process starting from Br replacement at the side chain followed by intramolecular aminodefluorination. The structures of some of the obtained heterocycles were confirmed using X-ray diffraction analysis. In addition, their inhibitory activity against influenza A/Puerto Rico/8/34 (H1N1) virus in MDCK cell culture was evaluated and compound-leader was found.",
keywords = "Anti-influenza virus activity, Aromatic nucleophilic substitution, Fluorinated heterocycles, Pentafluoropyridine, Tandem reaction, X-ray data",
author = "Larisa Politanskaya and Bulat Khasanov and Irina Bagryanskaya and Maria Niukalova and Sergey Aksakov and Irina Balashova and Zarubaev, {Vladimir V.}",
year = "2025",
month = apr,
day = "1",
doi = "10.1016/j.jfluchem.2025.110430",
language = "English",
volume = "283-284",
journal = "Journal of Fluorine Chemistry",
issn = "0022-1139",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Efficient synthesis, structure and anti-influenza virus activity of fluorinated pyrido[4,3-b][1,4]thiazine 1,1-dioxide derivatives.

AU - Politanskaya, Larisa

AU - Khasanov, Bulat

AU - Bagryanskaya, Irina

AU - Niukalova, Maria

AU - Aksakov, Sergey

AU - Balashova, Irina

AU - Zarubaev, Vladimir V.

PY - 2025/4/1

Y1 - 2025/4/1

N2 - A series of fluorinated bicyclic fused compounds, containing fragments of pyridine and 3,4-dihydro-2H-1,4-thiazine 1,1-dioxide were synthesized via one-pot substitution of halogen atoms by N-nucleophiles in polyfluorinated precursor. Formation of the heterocyclic moiety was proceed as a two-stage process starting from Br replacement at the side chain followed by intramolecular aminodefluorination. The structures of some of the obtained heterocycles were confirmed using X-ray diffraction analysis. In addition, their inhibitory activity against influenza A/Puerto Rico/8/34 (H1N1) virus in MDCK cell culture was evaluated and compound-leader was found.

AB - A series of fluorinated bicyclic fused compounds, containing fragments of pyridine and 3,4-dihydro-2H-1,4-thiazine 1,1-dioxide were synthesized via one-pot substitution of halogen atoms by N-nucleophiles in polyfluorinated precursor. Formation of the heterocyclic moiety was proceed as a two-stage process starting from Br replacement at the side chain followed by intramolecular aminodefluorination. The structures of some of the obtained heterocycles were confirmed using X-ray diffraction analysis. In addition, their inhibitory activity against influenza A/Puerto Rico/8/34 (H1N1) virus in MDCK cell culture was evaluated and compound-leader was found.

KW - Anti-influenza virus activity

KW - Aromatic nucleophilic substitution

KW - Fluorinated heterocycles

KW - Pentafluoropyridine

KW - Tandem reaction

KW - X-ray data

UR - https://www.mendeley.com/catalogue/d52e4250-5766-3fb5-88a6-673fdf82d817/

U2 - 10.1016/j.jfluchem.2025.110430

DO - 10.1016/j.jfluchem.2025.110430

M3 - Article

VL - 283-284

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

SN - 0022-1139

M1 - 110430

ER -

ID: 140479326