TY - JOUR

T1 - Effects of ionotropic glutamate channel blockers on audiogenic seizure reactions in Krushinskii-Molodkina rats

AU - Lukomskaya, N.Ya.

AU - Vataev, S.I.

AU - Zhabko, E.P.

AU - Magazanik, L.G.

PY - 2014

Y1 - 2014

N2 - Experiments on Krushinskii-Molodkina rats, with an inherited predisposition to audiogenic seizures, addressed the actions of a number of uncompetitive glutamate receptor blockers. Animals received i.m. doses of the selective NMDA receptor blockers memantine and IEM-1921, as well as the dicationic antagonists IEM-1925 and IEM-1754, which produce different levels of blockade of NMDA and Ca-permeable AMPA-kainate receptors, at different times (30 min or 1, 2, or 3 h) before delivery of sound stimuli. Effects on the latent period of initial motor responses were evaluated, along with influences on the signs of clonic seizures and tonic seizures with limb and tail extension. By 30 min after injection of IEM-1921 at a dose of 5 mg/kg, 33% of rats showed the complete absence of seizures in response to sound, while 59% of animals showed audiogenic convulsions only in the form of motor excitation without generalized clonic-tonic seizures. Memantine at a dose of 5 mg/kg did not induce complete blockade of seizures, thou

AB - Experiments on Krushinskii-Molodkina rats, with an inherited predisposition to audiogenic seizures, addressed the actions of a number of uncompetitive glutamate receptor blockers. Animals received i.m. doses of the selective NMDA receptor blockers memantine and IEM-1921, as well as the dicationic antagonists IEM-1925 and IEM-1754, which produce different levels of blockade of NMDA and Ca-permeable AMPA-kainate receptors, at different times (30 min or 1, 2, or 3 h) before delivery of sound stimuli. Effects on the latent period of initial motor responses were evaluated, along with influences on the signs of clonic seizures and tonic seizures with limb and tail extension. By 30 min after injection of IEM-1921 at a dose of 5 mg/kg, 33% of rats showed the complete absence of seizures in response to sound, while 59% of animals showed audiogenic convulsions only in the form of motor excitation without generalized clonic-tonic seizures. Memantine at a dose of 5 mg/kg did not induce complete blockade of seizures, thou

U2 - 10.1007/s11055-013-9877-y

DO - 10.1007/s11055-013-9877-y

M3 - Article

VL - 44

SP - 79

EP - 86

JO - Neuroscience and Behavioral Physiology

JF - Neuroscience and Behavioral Physiology

SN - 0097-0549

IS - 1

ER -