TY - JOUR

T1 - Effect of High-Fructose Diet on Physiological, Biochemical and Morphological Parameters of TAAR9 Knockout Female Rats

AU - Апрятин, Сергей Алексеевич

AU - Жуков, Илья Сергеевич

AU - Манасян, А. Л.

AU - Муртазина, Рамиля Зуфаровна

AU - Хунагов, Т.А.

AU - Лезина, А.И.

AU - Klimenko, V.M.

PY - 2021/9

Y1 - 2021/9

N2 - The discovery of the system of trace amines and their receptors twenty years ago opened new avenues for studying monoamine systems in the brain. However, of the six trace amine-associated receptors found in humans, mice and rats, only the TAAR1 receptor and its ligands are well studied. The biological functions of the remaining five receptors are currently unknown. We assessed behavioral, biochemical and morphological parameters of TAARR9 knockout (TAAR9-KO) female rats that received a 20% fructose solution instead of water for 2 months. Physiological changes were investigated in open field, elevated plus maze, and Morris water maze behavioral tests; also analyzed were changes in grooming microstructure. As a result, significant differences in exploratory activity, burrowing behavior and thermoregulation, as well as changes in some biochemical parameters and lipid accumulation in the liver, were revealed in TAAR9 gene knockout female rats.

AB - The discovery of the system of trace amines and their receptors twenty years ago opened new avenues for studying monoamine systems in the brain. However, of the six trace amine-associated receptors found in humans, mice and rats, only the TAAR1 receptor and its ligands are well studied. The biological functions of the remaining five receptors are currently unknown. We assessed behavioral, biochemical and morphological parameters of TAARR9 knockout (TAAR9-KO) female rats that received a 20% fructose solution instead of water for 2 months. Physiological changes were investigated in open field, elevated plus maze, and Morris water maze behavioral tests; also analyzed were changes in grooming microstructure. As a result, significant differences in exploratory activity, burrowing behavior and thermoregulation, as well as changes in some biochemical parameters and lipid accumulation in the liver, were revealed in TAAR9 gene knockout female rats.

KW - ACTIVATION

KW - AMPHETAMINE

KW - RECEPTORS

KW - STAIN

KW - TAAR9

KW - TRACE AMINES

KW - behavior

KW - fructose

KW - grooming

KW - trace amines

U2 - 10.1134/s0022093021050173

DO - 10.1134/s0022093021050173

M3 - Article

VL - 57

SP - 1163

EP - 1173

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 5

ER -