The serious problem of current day is the processes involved in wound healing and chronic wounds treatment. The best investing strategyin treatment of chronic wounds is the bactericidal effect of non-thermal atmospheric pressure plasma. The paper presents experimental results of full-skin wounds healing in mice on the background of immune suppression when treating the wound surface with non-thermal plasma. A comprehensive analysis of changes in the wound surface area, bacterial contamination and IL-10 level under the influence of non-thermal plasma revealed signs of accelerated re-epithelialization and stimulation of epithelial cell proliferation, indicating activation of the healing process.