Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
In Drosophila, blood development occurs in a specialized larval hematopoietic organ, the lymph gland (LG), within which stem-like hemocyte precursors or prohemocytes differentiate to multiple blood cell types. Here we show that components of the Wingless (Wg) signaling pathway are expressed in prohemocytes. Loss- and gain-of-function analysis indicates that canonical Wg signaling is required for maintenance of prohemocytes and negatively regulates their differentiation. Wg signals locally in a short-range fashion within different compartments of the LG. In addition, Wg signaling positively regulates the proliferation and maintenance of cells that function as a hematopoietic niche in Drosophila, the posterior signaling center (PSC), and in the proliferation of crystal cells. Our studies reveal a conserved function of Wg signaling in the maintenance of stem-like blood progenitors and reveal an involvement of this pathway in the regulation of hemocyte differentiation through its action in the hematopoietic niche.
Язык оригинала | английский |
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Страницы (с-по) | 756-763 |
Число страниц | 8 |
Журнал | Developmental Cell |
Том | 16 |
Номер выпуска | 5 |
DOI | |
Состояние | Опубликовано - 19 мая 2009 |
Опубликовано для внешнего пользования | Да |
ID: 50501764