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Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. / Laguna, Ariadna; Schintu, Nicoletta; Nobre, André; Alvarsson, Alexandra; Volakakis, Nikolaos; Jacobsen, Jesper Kjaer; Gómez-Galán, Marta; Sopova, Elena; Joodmardi, Eliza; Yoshitake, Takashi; Deng, Qiaolin; Kehr, Jan; Ericson, Johan; Svenningsson, Per; Shupliakov, Oleg; Perlmann, Thomas.

в: Nature Neuroscience, Том 18, № 6, 28.06.2015, стр. 826-835.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Laguna, A, Schintu, N, Nobre, A, Alvarsson, A, Volakakis, N, Jacobsen, JK, Gómez-Galán, M, Sopova, E, Joodmardi, E, Yoshitake, T, Deng, Q, Kehr, J, Ericson, J, Svenningsson, P, Shupliakov, O & Perlmann, T 2015, 'Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease', Nature Neuroscience, Том. 18, № 6, стр. 826-835. https://doi.org/10.1038/nn.4004

APA

Laguna, A., Schintu, N., Nobre, A., Alvarsson, A., Volakakis, N., Jacobsen, J. K., Gómez-Galán, M., Sopova, E., Joodmardi, E., Yoshitake, T., Deng, Q., Kehr, J., Ericson, J., Svenningsson, P., Shupliakov, O., & Perlmann, T. (2015). Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nature Neuroscience, 18(6), 826-835. https://doi.org/10.1038/nn.4004

Vancouver

Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK и пр. Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nature Neuroscience. 2015 Июнь 28;18(6):826-835. https://doi.org/10.1038/nn.4004

Author

Laguna, Ariadna ; Schintu, Nicoletta ; Nobre, André ; Alvarsson, Alexandra ; Volakakis, Nikolaos ; Jacobsen, Jesper Kjaer ; Gómez-Galán, Marta ; Sopova, Elena ; Joodmardi, Eliza ; Yoshitake, Takashi ; Deng, Qiaolin ; Kehr, Jan ; Ericson, Johan ; Svenningsson, Per ; Shupliakov, Oleg ; Perlmann, Thomas. / Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. в: Nature Neuroscience. 2015 ; Том 18, № 6. стр. 826-835.

BibTeX

@article{cc359e9b16bc4c57a4916d0e8bbe86f7,
title = "Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease",
abstract = "The role of developmental transcription factors in maintenance of neuronal properties and in disease remains poorly understood. Lmx1a and Lmx1b are key transcription factors required for the early specification of ventral midbrain dopamine (mDA) neurons. Here we show that conditional ablation of Lmx1a and Lmx1b after mDA neuron specification resulted in abnormalities that show striking resemblance to early cellular abnormalities seen in Parkinson's disease. We found that Lmx1b was required for the normal execution of the autophagic-lysosomal pathway and for the integrity of dopaminergic nerve terminals and long-term mDA neuronal survival. Notably, human LMX1B expression was decreased in mDA neurons in brain tissue affected by Parkinson's disease. Thus, these results reveal a sustained and essential requirement of Lmx1b for the function of midbrain mDA neurons and suggest that its dysfunction is associated with Parkinson's disease pathogenesis.",
author = "Ariadna Laguna and Nicoletta Schintu and Andr{\'e} Nobre and Alexandra Alvarsson and Nikolaos Volakakis and Jacobsen, {Jesper Kjaer} and Marta G{\'o}mez-Gal{\'a}n and Elena Sopova and Eliza Joodmardi and Takashi Yoshitake and Qiaolin Deng and Jan Kehr and Johan Ericson and Per Svenningsson and Oleg Shupliakov and Thomas Perlmann",
year = "2015",
month = jun,
day = "28",
doi = "10.1038/nn.4004",
language = "English",
volume = "18",
pages = "826--835",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

AU - Laguna, Ariadna

AU - Schintu, Nicoletta

AU - Nobre, André

AU - Alvarsson, Alexandra

AU - Volakakis, Nikolaos

AU - Jacobsen, Jesper Kjaer

AU - Gómez-Galán, Marta

AU - Sopova, Elena

AU - Joodmardi, Eliza

AU - Yoshitake, Takashi

AU - Deng, Qiaolin

AU - Kehr, Jan

AU - Ericson, Johan

AU - Svenningsson, Per

AU - Shupliakov, Oleg

AU - Perlmann, Thomas

PY - 2015/6/28

Y1 - 2015/6/28

N2 - The role of developmental transcription factors in maintenance of neuronal properties and in disease remains poorly understood. Lmx1a and Lmx1b are key transcription factors required for the early specification of ventral midbrain dopamine (mDA) neurons. Here we show that conditional ablation of Lmx1a and Lmx1b after mDA neuron specification resulted in abnormalities that show striking resemblance to early cellular abnormalities seen in Parkinson's disease. We found that Lmx1b was required for the normal execution of the autophagic-lysosomal pathway and for the integrity of dopaminergic nerve terminals and long-term mDA neuronal survival. Notably, human LMX1B expression was decreased in mDA neurons in brain tissue affected by Parkinson's disease. Thus, these results reveal a sustained and essential requirement of Lmx1b for the function of midbrain mDA neurons and suggest that its dysfunction is associated with Parkinson's disease pathogenesis.

AB - The role of developmental transcription factors in maintenance of neuronal properties and in disease remains poorly understood. Lmx1a and Lmx1b are key transcription factors required for the early specification of ventral midbrain dopamine (mDA) neurons. Here we show that conditional ablation of Lmx1a and Lmx1b after mDA neuron specification resulted in abnormalities that show striking resemblance to early cellular abnormalities seen in Parkinson's disease. We found that Lmx1b was required for the normal execution of the autophagic-lysosomal pathway and for the integrity of dopaminergic nerve terminals and long-term mDA neuronal survival. Notably, human LMX1B expression was decreased in mDA neurons in brain tissue affected by Parkinson's disease. Thus, these results reveal a sustained and essential requirement of Lmx1b for the function of midbrain mDA neurons and suggest that its dysfunction is associated with Parkinson's disease pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=84929880464&partnerID=8YFLogxK

U2 - 10.1038/nn.4004

DO - 10.1038/nn.4004

M3 - Article

C2 - 25915474

AN - SCOPUS:84929880464

VL - 18

SP - 826

EP - 835

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 6

ER -

ID: 40828204